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CTNNB1 抗体 (N-Term)

Name: CTNNB1 抗体 (N-Term)
SKU: ABIN6260494
Availability: OutOfStock

CTNNB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts of various sample,using Catenin-β antibody. (CTNNB1 抗体 (N-Term))

Western blot analysis of Catenin-β expression in 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (CTNNB1 抗体 (N-Term))

IF/ICC

ABIN6269220 showing positive staining in colon cancer tissue. (CTNNB1 抗体 (N-Term))

IHC

ABIN6269220 staining MCF-7 cells by ICC/IF. (CTNNB1 抗体 (N-Term))

IF/ICC

6 images

(6 references)

产品编号 ABIN6260494

发货至: 中国

Datasheet as PDF

抗原 See all CTNNB1 抗体

CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))
抗原表位
29

15

11

10

10

6

6

6

5

4

4

4

4

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
223

119

105

34

24

22

20

18

12

11

10

10

8

7

6

5

1
人, 小鼠, 大鼠
宿主
146

75

3

2
兔
Compatible Secondaries
克隆类型
145

81
多克隆
标记
187

8

5

4

4

4

4

4

1

1

1

1

1

1
This CTNNB1 antibody is un-conjugated
应用范围
198

95

90

76

45

40

34

29

12

6

5

3

3

3

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Beta Catenin Antibody detects endogenous levels of total beta Catenin.

预测反应

Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human beta Catenin, corresponding to a region within N-terminal amino acids.

亚型

IgG

Top Product

Discover our top product CTNNB1 Primary Antibody
anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (N-Term) antibody
KO Validated CTNNB1 适用: 人 WB, IHC, IF, FACS, IHC (p), IP, ICC, IHC (fro), ChIP, IHC (wm), CUT&RUN 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 2-781) antibody
CTNNB1 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 682-781) antibody
CTNNB1 适用: 人 WB, ELISA, IF, PLA, RNAi 宿主: 小鼠 Monoclonal 1C9 unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
CTNNB1 适用: 人 WB, IHC, IF, FACS, StM 宿主: 兔 Monoclonal CTNNB1-2030R unconjugated Recombinant Antibody

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
CTNNB1 适用: 人, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1E10 unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
CTNNB1 适用: 人, 大鼠, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 12H7 unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
CTNNB1 适用: 人, 大鼠, 犬, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 9H2 unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
CTNNB1 适用: 人, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 6A3 unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
CTNNB1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 9C1 unconjugated

anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) antibody
KO Validated CTNNB1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

1 mg/mL in PBS, pH 7.4.

储存条件

-20 °C

有效期

12 months
Tang, Peng, Huang, Xie, Chen, Shen, Gao, You, Xie, Chen: "Neoisoliquiritigenin Inhibits Tumor Progression by Targeting GRP78-β- catenin Signaling in Breast Cancer." in: Current cancer drug targets, Vol. 18, Issue 4, pp. 390-399, (2018) (PubMed).

Zheng, Zhang, Yang, Cui, Sun, Liang, Qin, Yang, Liu, Yan: "MicroRNA-200c impairs uterine receptivity formation by targeting FUT4 and α1,3-fucosylation." in: Cell death and differentiation, Vol. 24, Issue 12, pp. 2161-2172, (2018) (PubMed).

Shao, Zhang, Ma, Lu, Meng, Li, Wang, Chen, Zhang, Han, Liu, Ma: "MicroRNA-139-5p affects cisplatin sensitivity in human nasopharyngeal carcinoma cells by regulating the epithelial-to-mesenchymal transition." in: Gene, Vol. 652, pp. 48-58, (2018) (PubMed).

Li, Liu, Zhang, Cui, Ge, Wang, Chen: "Upregulation of E‑cadherin expression mediated by a novel dsRNA suppresses the growth and metastasis of bladder cancer cells by inhibiting β-catenin/TCF target genes." in: International journal of oncology, Vol. 52, Issue 6, pp. 1815-1826, (2018) (PubMed).

Huang, Song, Tao, Shao, Zeng, Xu, Qi, Sun: "Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells." in: PLoS ONE, Vol. 13, Issue 4, pp. e0195610, (2018) (PubMed).

Zhang, Zhang, Bulbul, Shan, Wang, Yan: "Baicalin promotes embryo adhesion and implantation by upregulating fucosyltransferase IV (FUT4) via Wnt/beta-catenin signaling pathway." in: FEBS letters, Vol. 589, Issue 11, pp. 1225-33, (2015) (PubMed).
抗原

CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

别名

CTNNB1 (CTNNB1 产品)

别名

Jup antibody, LOC100217813 antibody, CTNNB1 antibody, CTNNB antibody, Bfc antibody, Catnb antibody, Mesc antibody, ctnnb antibody, id:ibd2058 antibody, wu:fb73e10 antibody, wu:fi81c06 antibody, wu:fk25h01 antibody, ctnnb1 antibody, CHBCAT antibody, MRD19 antibody, armadillo antibody, beta-catenin antibody, catenin beta 1 antibody, catenin (cadherin associated protein), beta 1 antibody, catenin (cadherin-associated protein), beta 1 antibody, catenin beta 1 S homeolog antibody, catenin beta 1 L homeolog antibody, CTNNB1 antibody, Ctnnb1 antibody, ctnnb1 antibody, ctnnb1.S antibody, ctnnb1.L antibody

背景

Description: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
Gene: CTNNB1

分子量

92kDa

基因ID

1499

UniProt

P35222

途径

WNT signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2