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CARD9 抗体 (C-Term)

CARD9 适用: 人, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6260462
发货至: 中国
  • 抗原 See all CARD9 抗体
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    抗原表位
    • 15
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 40
    • 3
    • 3
    • 2
    • 2
    • 1
    人, 小鼠
    宿主
    • 38
    • 3
    克隆类型
    • 40
    • 1
    多克隆
    标记
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CARD9 antibody is un-conjugated
    应用范围
    • 34
    • 13
    • 13
    • 9
    • 7
    • 6
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    CARD9 Antibody detects endogenous levels of total CARD9.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Dog,Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human CARD9, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product CARD9 Primary Antibody
  • 应用备注
    WB 1:1000-3000, IF/ICC 1:200-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    CARD9 (Caspase Recruitment Domain Family, Member 9 (CARD9))
    别名
    CARD9 (CARD9 产品)
    别名
    Gm782 antibody, card9 antibody, CANDF2 antibody, hCARD9 antibody, caspase recruitment domain family, member 9 antibody, caspase recruitment domain family member 9 antibody, Card9 antibody, CARD9 antibody, card9 antibody
    背景

    Description: Adapter protein that plays a key role in innate immune response to a number of intracellular pathogens, such as C.albicans and L.monocytogenes. Is at the crossroads of ITAM-tyrosine kinase and the Toll-like receptors (TLR) and NOD2 signaling pathways. Probably controls various innate immune response pathways depending on the intracellular pathogen. In response to L.monocytogenes infection, acts by connecting NOD2 recognition of peptidoglycan to downstream activation of MAP kinases (MAPK) without activating NF-kappa-B. Also involved in activation of myeloid cells via classical ITAM-associated receptors and TLR: required for TLR-mediated activation of MAPK, while it is not required for TLR-induced activation of NF-kappa-B (By similarity). Controls CLEC7A (dectin-1)-mediated myeloid cell activation induced by the yeast cell wall component zymosan, leading to cytokine production and innate anti-fungal immunity: acts by regulating BCL10-MALT1-mediated NF-kappa-B activation pathway. Activates NF-kappa-B via BCL10. In response to the hyphal form of C.albicans, mediates CLEC6A (dectin-2)-induced I-kappa-B kinase ubiquitination, leading to NF-kappa-B activation via interaction with BCL10. In response to fungal infection, may be required for the development and subsequent differentiation of interleukin 17-producing T helper (TH-17) cells.

    Gene: CARD9

    分子量
    62 kDa
    基因ID
    64170
    UniProt
    Q9H257
    途径
    Activation of Innate immune Response
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