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- 抗原 See all CAMK2D 抗体
- CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CAMK2D antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- CAMK2D Antibody detects endogenous levels of total CAMK2D.
- 预测反应
- Pig,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CAMK2D, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CAMK2D Primary Antibody
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anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) antibody
KO Validated CAMK2D 适用: 人 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 301-410) antibodyCAMK2D 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (Internal Region) antibodyCAMK2D 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) antibodyCAMK2D 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 221-250) antibodyCAMK2D 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB34171 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 1-260) antibodyCAMK2D 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 301-410) antibodyCAMK2D 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 301-410) antibodyCAMK2D 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 448-478), (C-Term) antibodyCAMK2D 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1259 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 448-478), (C-Term) antibodyCAMK2D 适用: 人, 猴 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))
- 别名
- CAMK2D (CAMK2D 产品)
- 别名
- CAMKD antibody, CAMK1 antibody, Camk2 antibody, Camki antibody, RATCAMKI antibody, camk2 antibody, camkd antibody, camkII antibody, 2810011D23Rik antibody, 8030469K03Rik antibody, [d]-CaMKII antibody, mKIAA4163 antibody, calcium/calmodulin dependent protein kinase II delta antibody, calcium/calmodulin-dependent protein kinase II delta antibody, calcium/calmodulin dependent protein kinase (CaM kinase) II delta S homeolog antibody, calcium/calmodulin dependent protein kinase (CaM kinase) II delta antibody, calcium/calmodulin-dependent protein kinase II, delta antibody, CAMK2D antibody, Camk2d antibody, camk2d.S antibody, camk2d antibody
- 背景
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Description: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
Gene: CAMK2D
- 分子量
- 56 kDa
- 基因ID
- 817
- UniProt
- Q13557
- 途径
- WNT signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
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