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- 抗原 See all ANGPTL3 抗体
- ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ANGPTL3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- ANGPTL3 Antibody detects endogenous levels of total ANGPTL3.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human ANGPTL3, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ANGPTL3 Primary Antibody
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anti-Angiopoietin-Like 3 (ANGPTL3) (AA 17-460) antibody
ANGPTL3 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3B7 unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) antibodyANGPTL3 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) (AA 21-120) antibodyANGPTL3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) (AA 22-281) antibodyANGPTL3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) (AA 361-460) antibodyANGPTL3 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3F11 unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) antibodyANGPTL3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) (AA 237-455) antibodyANGPTL3 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) (AA 82-114) antibodyANGPTL3 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) (AA 17-268) antibodyANGPTL3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin-Like 3 (ANGPTL3) (AA 1-460) antibodyANGPTL3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- ANGPTL3 (Angiopoietin-Like 3 (ANGPTL3))
- 别名
- ANGPTL3 (ANGPTL3 产品)
- 别名
- fb60e11 antibody, fb66h02 antibody, wu:fb60e11 antibody, wu:fb66h02 antibody, zgc:111943 antibody, ANGPTL3 antibody, LOC100230785 antibody, ANG-5 antibody, ANGPT5 antibody, ANL3 antibody, FHBL2 antibody, hypl antibody, angiopoietin-like 3 antibody, angiopoietin like 3 antibody, angptl3 antibody, ANGPTL3 antibody, Angptl3 antibody
- 背景
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Description: Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism (PubMed:11788823, PubMed:12909640, PubMed:23661675, PubMed:25495645). Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake (By similarity). Has a stimulatory effect on plasma triglycerides (TG), which is achieved by suppressing plasma TG clearance via inhibition of LPL activity. The inhibition of LPL activity appears to be an indirect mechanism involving recruitment of proprotein convertases PCSK6 and FURIN to LPL leading to cleavage and dissociation of LPL from the cell surface, the function does not require ANGPTL3 proteolytic cleavage but seems to be mediated by the N-terminal domain, and is not inhibited by GPIHBP1 (PubMed:12097324, PubMed:19318355, PubMed:20581395). Can inhibit endothelial lipase, causing increased plasma levels of high density lipoprotein (HDL) cholesterol and phospholipids (PubMed:17110602, PubMed:19028676). Can bind to adipocytes to activate lipolysis, releasing free fatty acids and glycerol (PubMed:12565906). Suppresses LPL specifically in oxidative tissues which is required to route very low density lipoprotein (VLDL)-TG to white adipose tissue (WAT) for storage in response to food, the function may involve cooperation with circulating, liver-derived ANGPTL8 and ANGPTL4 expression in WAT (By similarity). Contributes to lower plasma levels of low density lipoprotein (LDL)-cholesterol by a mechanism that is independent of the canonical pathway implicating APOE and LDLR. May stimulate hypothalamic LPL activity (By similarity).
Gene: ANGPTL3
- 分子量
- 54kDa
- 基因ID
- 27329
- UniProt
- Q9Y5C1
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