AKAP8 抗体 (Internal Region)
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- 抗原 See all AKAP8 抗体
- AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This AKAP8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- AKAP8 Antibody detects endogenous levels of total AKAP8.
- 预测反应
- Bovine,Horse,Sheep,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human AKAP8, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product AKAP8 Primary Antibody
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anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 551-662) antibody
AKAP8 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 3D4 unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 1-692) antibodyAKAP8 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (Internal Region) antibodyAKAP8 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (Internal Region) antibodyAKAP8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 1-692) antibodyAKAP8 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 480-692) antibodyAKAP8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 331-380) antibodyAKAP8 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 395-430) antibodyAKAP8 适用: 人 WB 宿主: 兔 Polyclonal RB52720 unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) (AA 395-444) antibodyAKAP8 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 8 (AKAP8) antibodyAKAP8 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- AKAP8 (A Kinase (PRKA) Anchor Protein 8 (AKAP8))
- 别名
- AKAP8 (AKAP8 产品)
- 别名
- MGC108502 antibody, AKAP8 antibody, AKAP 95 antibody, AKAP-8 antibody, AKAP-95 antibody, AKAP95 antibody, 1200016A02Rik antibody, AA673585 antibody, AU015639 antibody, Akap95 antibody, A-kinase anchoring protein 8 antibody, A kinase (PRKA) anchor protein 8 antibody, AKAP8 antibody, akap8 antibody, Akap8 antibody
- 背景
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Description: Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II) (PubMed:9473338). Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation, the function appears to be independent from PKA-anchoring (PubMed:10601332, PubMed:10791967, PubMed:11964380). May help to deliver cyclin D/E to CDK4 to facilitate cell cycle progression (PubMed:14641107). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3, in this function may act redundantly with AKAP8L (PubMed:16980585). Involved in nuclear retention of RPS6KA1 upon ERK activation thus inducing cell proliferation (PubMed:22130794). May be involved in regulation of DNA replication by acting as scaffold for MCM2 (PubMed:12740381). Enhances HMT activity of the KMT2 family MLL4/WBP7 complex and is involved in transcriptional regulation. In a teratocarcinoma cell line is involved in retinoic acid-mediated induction of developmental genes implicating H3 'Lys-4' methylation (PubMed:23995757). May be involved in recruitment of active CASP3 to the nucleus in apoptotic cells (PubMed:16227597). May act as a carrier protein of GJA1 for its transport to the nucleus (PubMed:26880274). Seems to involved in modulation of rDNA transcription. Preferentially binds GC-rich DNA in vitro and associates to GC-rich ribosomal RNA promoters (PubMed:26683827). Involved in modulation of Toll-like receptor signaling. Required for the cAMP-dependent suppression of TNF-alpha in early stages of LPS-induced macrophage activation, the function probably implicates targeting of PKA to NFKB1 (By similarity).
Gene: AKAP8
- 分子量
- 76kDa
- 基因ID
- 10270
- UniProt
- O43823
- 途径
- SARS-CoV-2 Protein Interactome
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