CCAR2 抗体 (Internal Region)
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- 抗原 See all CCAR2 抗体
- CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
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抗原表位
- Internal Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CCAR2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- DBC1 Antibody detects endogenous levels of total DBC1.
- 预测反应
- Horse
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human DBC1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CCAR2 Primary Antibody
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anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibody
CCAR2 适用: 人, 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 1-923) antibodyCCAR2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 654-923) antibodyCCAR2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 5-365) antibodyCCAR2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) antibodyCCAR2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cell Cycle and Apoptosis Regulator 2 (CCAR2) (AA 842-855) antibodyVerified CCAR2 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CCAR2 (Cell Cycle and Apoptosis Regulator 2 (CCAR2))
- 别名
- CCAR2 (CCAR2 产品)
- 别名
- DBC-1 antibody, DBC1 antibody, KIAA1967 antibody, NET35 antibody, p30 DBC antibody, p30DBC antibody, 2610301G19Rik antibody, mKIAA1967 antibody, RGD1309922 antibody, Kiaa1967 antibody, cell cycle and apoptosis regulator 2 antibody, cell cycle activator and apoptosis regulator 2 antibody, CCAR2 antibody, Ccar2 antibody
- 背景
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Description: Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation (PubMed:18235501, PubMed:18235502, PubMed:19131338, PubMed:19218236, PubMed:22446626, PubMed:23352644, PubMed:23398316). Represses the ligand-dependent transcriptional activation function of ESR2 (PubMed:20074560). Acts as a regulator of PCK1 expression and gluconeogenesis by a mechanism that involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752). Negatively regulates the deacetylase activity of HDAC3 and can alter its subcellular localization (PubMed:21030595). Positively regulates the beta-catenin pathway (canonical Wnt signaling pathway) and is required for MCC-mediated repression of the beta-catenin pathway (PubMed:24824780). Represses ligand-dependent transcriptional activation function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with NR1H3 (PubMed:25661920). Plays an important role in tumor suppression through p53/TP53 regulation, stabilizes p53/TP53 by affecting its interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the transcriptional activator activity of BRCA1 (PubMed:20160719). Inhibits SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity of CHEK2 in vitro (PubMed:25361978).
Gene: CCAR2
- 分子量
- 102 kDa
- 基因ID
- 57805
- UniProt
- Q8N163
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