CHFR 抗体
Quick Overview for CHFR 抗体 (ABIN6259505)
抗原
See all CHFR 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- CHFR Antibody detects endogenous levels of total CHFR
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide
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亚型
- IgG
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anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 1-652) antibody
CHFR 适用: 人 ELISA, WB, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1H3-A12 unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 141-422) antibodyCHFR 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 136-194) antibodyCHFR 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2B11 unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 36-85) antibodyCHFR 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, 斑马鱼, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (C-Term) antibodyCHFR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (C-Term) antibodyVerified CHFR 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (AA 1-290) antibodyCHFR 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Checkpoint with Forkhead and Ring Finger Domains (CHFR) (N-Term) antibodyCHFR 适用: 人, 小鼠, 大鼠, 豚鼠, 兔, 斑马鱼, Cow, 犬, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500~1:1000, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C.Stable for 12 months from date of receipt
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有效期
- 12 months
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- CHFR (Checkpoint with Forkhead and Ring Finger Domains (CHFR))
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别名
- CHFR
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背景
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Description: E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Gene: CHFR
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分子量
- 73 kDa
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基因ID
- 55743
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UniProt
- Q96EP1
抗原
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