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- 抗原 See all NFE2L1 抗体
- NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NFE2L1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- NFE2L1 Antibody detects endogenous levels of total NFE2L1.
- 预测反应
- Pig,Bovine,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human NFE2L1, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product NFE2L1 Primary Antibody
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anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) antibody
NFE2L1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) (AA 515-772) antibodyNFE2L1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) antibodyNFE2L1 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal NRF1-2609 unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) (AA 251-550) antibodyNFE2L1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) antibodyNFE2L1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) (AA 677-771) antibodyNFE2L1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) (C-Term) antibodyNFE2L1 适用: 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 猴, Hamster, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) (AA 575-624) antibodyNFE2L1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1) (C-Term) antibodyNFE2L1 适用: 人, 小鼠, 大鼠, Cow, 犬, 兔 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- NFE2L1 (Nuclear Factor (erythroid-Derived 2)-Like 1 (NFE2L1))
- 别名
- NFE2L1 (NFE2L1 产品)
- 别名
- LCR-F1 antibody, NRF1 antibody, TCF11 antibody, AA408798 antibody, AW212678 antibody, Lcrf1 antibody, TCF-11 antibody, nfe2l1 antibody, nuclear factor, erythroid 2 like 1 antibody, nuclear factor, erythroid derived 2,-like 1 antibody, nuclear factor, erythroid 2-like 1 antibody, nuclear factor, erythroid 2 like 1 S homeolog antibody, nuclear factor, erythroid 2-like 1a antibody, NFE2L1 antibody, Nfe2l1 antibody, nfe2l1.S antibody, nfe2l1a antibody
- 背景
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Description: Endoplasmic reticulum membrane sensor NFE2L1: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (PubMed:20932482, PubMed:24448410). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (PubMed:20932482). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (PubMed:20932482).
Gene: NFE2L1
- 分子量
- 82 kDa
- 基因ID
- 4779
- UniProt
- Q14494
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