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APITD1 抗体 (C-Term)

APITD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6259030
发货至: 中国
  • 抗原 See all APITD1 抗体
    APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))
    抗原表位
    • 7
    • 6
    • 6
    • 6
    • 3
    • 1
    C-Term
    适用
    人, 小鼠, 大鼠
    宿主
    • 22
    • 2
    克隆类型
    • 23
    • 1
    多克隆
    标记
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APITD1 antibody is un-conjugated
    应用范围
    • 17
    • 14
    • 12
    • 12
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    特异性
    CENPS Antibody detects endogenous levels of total CENPS.
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human CENPS, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product APITD1 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))
    别名
    CENPS (APITD1 产品)
    别名
    CENP-S antibody, CENPS antibody, FAAP16 antibody, MHF1 antibody, 2610040C18Rik antibody, 2810407L01Rik antibody, cenps antibody, mhf1 antibody, APITD1 antibody, Apitd1 antibody, Mhf1 antibody, apitd1 antibody, zgc:194319 antibody, centromere protein S antibody, apoptosis-inducing, TAF9-like domain 1 antibody, centromere protein S L homeolog antibody, CENPS antibody, Cenps antibody, cenps.L antibody, APITD1 antibody, cenps antibody
    背景

    Description: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429).

    Gene: CENPS

    分子量
    16 kDa
    基因ID
    100526739, 378708
    UniProt
    Q8N2Z9
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