APITD1 抗体 (C-Term)
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- 抗原 See all APITD1 抗体
- APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))
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抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This APITD1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- CENPS Antibody detects endogenous levels of total CENPS.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CENPS, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product APITD1 Primary Antibody
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anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 1-138) antibody
APITD1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 48-74) antibodyAPITD1 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB23840 unconjugated
anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 1-138) antibodyAPITD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6F16 unconjugated
anti-Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1) (AA 1-138) antibodyAPITD1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- APITD1 (Apoptosis-Inducing, TAF9-Like Domain 1 (APITD1))
- 别名
- CENPS (APITD1 产品)
- 别名
- CENP-S antibody, CENPS antibody, FAAP16 antibody, MHF1 antibody, 2610040C18Rik antibody, 2810407L01Rik antibody, cenps antibody, mhf1 antibody, APITD1 antibody, Apitd1 antibody, Mhf1 antibody, apitd1 antibody, zgc:194319 antibody, centromere protein S antibody, apoptosis-inducing, TAF9-like domain 1 antibody, centromere protein S L homeolog antibody, CENPS antibody, Cenps antibody, cenps.L antibody, APITD1 antibody, cenps antibody
- 背景
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Description: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:20347428, PubMed:20347429). In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM (PubMed:20347428, PubMed:20347429). In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428). In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression (PubMed:19620631). As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure (PubMed:20347428, PubMed:22304917). DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own (PubMed:20347428, PubMed:20347429).
Gene: CENPS
- 分子量
- 16 kDa
- 基因ID
- 100526739, 378708
- UniProt
- Q8N2Z9
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