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IREM1 抗体 (Internal Region)

IREM1 适用: 人 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258909
发货至: 中国
  • 抗原 See all IREM1 抗体
    IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
    抗原表位
    • 8
    • 8
    • 7
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 36
    • 3
    • 1
    宿主
    • 37
    • 1
    克隆类型
    • 37
    • 1
    多克隆
    标记
    • 18
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IREM1 antibody is un-conjugated
    应用范围
    • 26
    • 25
    • 16
    • 15
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    CLM-1 Antibody detects endogenous levels of total CLM-1.
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human CLM-1, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product IREM1 Primary Antibody
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    IREM1 (Immune Receptor Expressed On Myeloid Cells 1 (IREM1))
    别名
    CD300LF (IREM1 产品)
    别名
    CLIM1 antibody, CLM-1 antibody, CLM1 antibody, Digr2 antibody, F730004D16Rik antibody, IREM1 antibody, IgSF13 antibody, LMIR3 antibody, Pigr3 antibody, CD300f antibody, RGD1309733 antibody, IREM-1 antibody, NKIR antibody, CD300 molecule like family member F antibody, Cd300 molecule-like family member F antibody, CD300 molecule like family member f antibody, Cd300lf antibody, CD300LF antibody
    背景

    Description: Acts as an inhibitory receptor for myeloid cells and mast cells (PubMed:15549731). Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition, recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis (By similarity). Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands (PubMed:24035150). May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling (By similarity). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:22043923). Inhibits osteoclast formation. Induces macrophage cell death upon engagement (By similarity).

    Gene: CD300LF

    分子量
    30 kDa
    基因ID
    146722
    UniProt
    Q8TDQ1
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