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- 抗原 See all GNA12 抗体
- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
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抗原表位
- C-Term
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GNA12 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- GNA12 Antibody detects endogenous levels of total GNA12.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GNA12, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product GNA12 Primary Antibody
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anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (AA 112-270) antibody
GNA12 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (AA 301-381) antibodyGNA12 适用: 人 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Internal Region) antibodyVerified GNA12 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (AA 146-195) antibodyGNA12 适用: 人, 大鼠, 小鼠, 犬, 兔, 豚鼠, 马, Cow, 斑马鱼, 猴, Pig, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Ser67) antibodyGNA12 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (AA 1-200) antibodyGNA12 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12) (Middle Region) antibodyGNA12 适用: 人, 大鼠, 小鼠, 犬, 兔, 豚鼠, 马, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- GNA12 (Guanine Nucleotide Binding Protein (G Protein) alpha 12 (GNA12))
- 别名
- GNA12 (GNA12 产品)
- 别名
- NNX3 antibody, RMP antibody, gep antibody, gna12 antibody, gna12l antibody, AI414047 antibody, AI504261 antibody, Galpha12 antibody, G protein subunit alpha 12 antibody, guanine nucleotide binding protein (G protein) alpha 12a antibody, guanine nucleotide binding protein, alpha 12 antibody, GNA12 antibody, Gna12 antibody, gna12a antibody
- 背景
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Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:22609986, PubMed:15525651, PubMed:15240885, PubMed:17565996, PubMed:12515866, PubMed:16787920, PubMed:16705036, PubMed:23762476, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866, PubMed:16202387). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (PubMed:15525651, PubMed:17565996). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating proinflammatory cytokine production (PubMed:23762476, PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333, PubMed:16787920). Together with NAPA promotes CDH5 localization to plasma membrane (PubMed:15980433). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986).
Gene: GNA12
- 分子量
- 44 kDa.
- 基因ID
- 2768
- UniProt
- Q03113
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