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- 抗原 See all KAT2A 抗体
- KAT2A (K(lysine) Acetyltransferase 2A (KAT2A))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KAT2A antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- GCN5L2 Antibody detects endogenous levels of total GCN5L2.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GCN5L2, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product KAT2A Primary Antibody
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anti-K(lysine) Acetyltransferase 2A (KAT2A) antibody
KAT2A 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 1-100) antibodyKAT2A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 738-837) antibodyKAT2A 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4D3 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 738-837) antibodyKAT2A 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 738-837) antibodyKAT2A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4F9 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (C-Term) antibodyKAT2A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (C-Term) antibodyKAT2A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 411-837) antibodyKAT2A 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal AT3G13 unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 807-837) antibodyKAT2A 适用: 人, 小鼠 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-K(lysine) Acetyltransferase 2A (KAT2A) (AA 302-537) antibodyKAT2A 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- KAT2A (K(lysine) Acetyltransferase 2A (KAT2A))
- 别名
- KAT2A (KAT2A 产品)
- 别名
- KAT2A antibody, GCN5L2 antibody, GCN5 antibody, PCAF-b antibody, hGCN5 antibody, 1110051E14Rik antibody, AW212720 antibody, Gcn5 antibody, Gcn5l2 antibody, mmGCN5 antibody, K(lysine) acetyltransferase 2A antibody, lysine acetyltransferase 2A antibody, histone acetyltransferase KAT2A antibody, ras-related protein Rab-5C antibody, KAT2A antibody, LOC100176452 antibody, LOC100597293 antibody, Kat2a antibody
- 背景
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Description: Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
Gene: KAT2A
- 分子量
- 100 kDa
- 基因ID
- 2648
- UniProt
- Q92830
- 途径
- Chromatin Binding, Tube Formation
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