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FZD6 抗体 (C-Term)

FZD6 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258792
发货至: 中国
  • 抗原 See all FZD6 抗体
    FZD6 (Frizzled Family Receptor 6 (FZD6))
    抗原表位
    • 8
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 36
    • 12
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    人, 小鼠
    宿主
    • 36
    • 2
    • 2
    • 1
    克隆类型
    • 39
    • 2
    多克隆
    标记
    • 28
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FZD6 antibody is un-conjugated
    应用范围
    • 25
    • 16
    • 6
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    FZD6 Antibody detects endogenous levels of total FZD6.
    预测反应
    Rabbit
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human FZD6, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product FZD6 Primary Antibody
  • 应用备注
    WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    FZD6 (Frizzled Family Receptor 6 (FZD6))
    别名
    FZD6 (FZD6 产品)
    别名
    zgc:65879 antibody, zgc:77440 antibody, fz6 antibody, frz6 antibody, Xfrz6 antibody, frizzled6 antibody, frizzled-6 antibody, FZ-6 antibody, FZ6 antibody, HFZ6 antibody, NDNC10 antibody, Frizzled-6 antibody, Fz6 antibody, frizzled class receptor 6 antibody, frizzled class receptor 6 S homeolog antibody, fzd6 antibody, fzd6.S antibody, FZD6 antibody, Fzd6 antibody
    背景

    Description: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity).

    Gene: FZD6

    分子量
    79 kDa
    基因ID
    8323
    UniProt
    O60353
    途径
    WNT signaling, Tube Formation
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