Fgr 抗体 (Internal Region)
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- 抗原 See all Fgr (FGR) 抗体
- Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Fgr antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- FGR Antibody detects endogenous levels of total FGR.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human FGR, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product FGR Primary Antibody
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anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-90) antibody
FGR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3G10 unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 3-33), (N-Term) antibodyFGR 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal RB3095 unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 11-72) antibodyFGR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) antibodyFGR 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 6G2 unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 11-40), (N-Term) antibodyFGR 适用: 人 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-529) antibodyFGR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-529) antibodyFGR 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (C-Term) antibodyVerified FGR 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 1-100) antibodyFGR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR) (AA 232-265) antibodyFGR 适用: 大鼠 WB 宿主: 兔 Polyclonal RB50283 unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- Fgr (FGR) (Gardner-Rasheed Feline Sarcoma Viral (V-Fgr) Oncogene Homolog (FGR))
- 别名
- FGR (FGR 产品)
- 别名
- SRC2 antibody, c-fgr antibody, c-src2 antibody, p55-Fgr antibody, p55c-fgr antibody, p58-Fgr antibody, p58c-fgr antibody, FGR proto-oncogene, Src family tyrosine kinase antibody, FGR antibody, Fgr antibody
- 背景
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Description: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1.
Gene: FGR
- 分子量
- 55 kDa
- 基因ID
- 2268
- UniProt
- P09769
- 途径
- Sensory Perception of Sound, Stem Cell Maintenance, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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