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ARID1B 抗体 (Internal Region)

ARID1B 适用: 人, 大鼠, 小鼠 WB, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258593
发货至: 中国
  • 抗原 See all ARID1B 抗体
    ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))
    抗原表位
    • 15
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 31
    • 19
    • 13
    • 3
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 44
    • 2
    克隆类型
    • 44
    • 2
    多克隆
    标记
    • 18
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    • 1
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    • 1
    • 1
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    This ARID1B antibody is un-conjugated
    应用范围
    • 27
    • 13
    • 13
    • 11
    • 9
    • 9
    • 9
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC)
    特异性
    BAF250B Antibody detects endogenous levels of total BAF250B.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human BAF250B, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product ARID1B Primary Antibody
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    ARID1B (AT Rich Interactive Domain 1B (SWI1-Like) (ARID1B))
    别名
    ARID1B (ARID1B 产品)
    别名
    fd07d11 antibody, si:dkey-60a16.3 antibody, wu:fd07d11 antibody, 8030481M12 antibody, 9330189K18Rik antibody, AI836955 antibody, Ardi1b antibody, B230217J03Rik antibody, mKIAA1235 antibody, 6A3-5 antibody, Smcf1 antibody, smcf-1 antibody, BAF250B antibody, BRIGHT antibody, DAN15 antibody, ELD/OSA1 antibody, MRD12 antibody, OSA2 antibody, P250R antibody, AT rich interactive domain 1B (SWI1-like) antibody, AT rich interactive domain 1B (SWI-like) antibody, AT-rich interaction domain 1B antibody, arid1b antibody, Arid1b antibody, ARID1B antibody
    背景

    Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).

    Gene: ARID1B

    分子量
    170 kDa
    基因ID
    57492
    UniProt
    Q8NFD5
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