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RHOH 抗体 (Internal Region)

RHOH 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258315
发货至: 中国
  • 抗原 See all RHOH 抗体
    RHOH (Ras Homolog Family Member H (RHOH))
    抗原表位
    • 13
    • 11
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 40
    • 16
    • 14
    • 1
    人, 小鼠, 大鼠
    宿主
    • 37
    • 3
    克隆类型
    • 38
    • 2
    多克隆
    标记
    • 19
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This RHOH antibody is un-conjugated
    应用范围
    • 25
    • 25
    • 10
    • 7
    • 4
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    RhoH Antibody detects endogenous levels of total RhoH.
    预测反应
    Dog
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human RhoH, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product RHOH Primary Antibody
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    RHOH (Ras Homolog Family Member H (RHOH))
    别名
    RHOH (RHOH 产品)
    别名
    ARHH antibody, TTF antibody, 5830400A04Rik antibody, AU019774 antibody, Arhh antibody, ras homolog family member H antibody, RHOH antibody, Rhoh antibody
    背景

    Description: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca2+ mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils.

    Gene: RHOH

    分子量
    21 kDa
    基因ID
    399
    UniProt
    Q15669
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