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RORA 抗体 (N-Term)

Name: RORA 抗体 (N-Term)
SKU: ABIN6258311
Availability: OutOfStock

RORA 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from HeLa cells using RORA antibody. (RORA 抗体 (N-Term))

IF/ICC

ABIN6274239 at 1/100 staining Human gastric tissue by IHC-P. (RORA 抗体 (N-Term))

IHC

3 images

产品编号 ABIN6258311

发货至: 中国

Datasheet as PDF

抗原 See all RORA 抗体

RORA (RAR-Related Orphan Receptor A (RORA))
抗原表位
9

7

7

6

4

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
71

31

29

13

13

10

10

8

8

7

7

6

6

4

3

2

1
人, 大鼠
宿主
66

5
兔
Compatible Secondaries
克隆类型
67

4
多克隆
标记
45

4

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This RORA antibody is un-conjugated
应用范围
55

24

15

9

9

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

RORA Antibody detects endogenous levels of total RORA.

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human RORA, corresponding to a region within N-terminal amino acids.

亚型

IgG

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anti-RAR-Related Orphan Receptor A (RORA) antibody
KO Validated RORA 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (Middle Region) antibody
RORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 山羊, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (Hinge Region) antibody
RORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 猴, Pig, Bat, Hamster IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (AA 193-222) antibody
RORA 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB16632 unconjugated

anti-RAR-Related Orphan Receptor A (RORA) antibody
RORA 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (AA 1-468) antibody
RORA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (Ligand Binding Domain) antibody
RORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 猴, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (AA 50-99) antibody
RORA 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (AA 239-288) antibody
RORA 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 猴, 山羊, Pig, 斑马鱼, Bat, 绵羊, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-RAR-Related Orphan Receptor A (RORA) (AA 36-85) antibody
RORA 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

RORA (RAR-Related Orphan Receptor A (RORA))

别名

RORA (RORA 产品)

别名

ror1 antibody, ror2 antibody, ror3 antibody, rzra antibody, nr1f1 antibody, MGC146531 antibody, NR1F1 antibody, ROR1 antibody, ROR2 antibody, ROR3 antibody, RZR-ALPHA antibody, RZRA antibody, RORalpha-B antibody, gb:dq017624 antibody, rora2 antibody, 9530021D13Rik antibody, Nr1f1 antibody, nmf267 antibody, sg antibody, staggerer antibody, tmgc26 antibody, RORalpha1 antibody, RAR related orphan receptor A antibody, RAR-related orphan receptor A antibody, RAR-related orphan receptor A, paralog a antibody, RAR-related orphan receptor alpha antibody, RORA antibody, rora antibody, Rora antibody, roraa antibody

背景

Description: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regulates SHH gene expression, among others, to induce granule cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. Regulates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Regulates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modulator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SULT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regulation of genes involved in cholesterol metabolism. Also involved in the regulation of hepatic glucose metabolism through the modulation of G6PC and PCK1. In adipose tissue, plays a role as negative regulator of adipocyte differentiation, probably acting through dual mechanisms. May suppress CEBPB-dependent adipogenesis through direct interaction and PPARG-dependent adipogenesis through competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4+ T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regulates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellular stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling.
Gene: RORA

分子量

60 kDa

基因ID

6095

UniProt

P35398

途径

Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha