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PIK3C2A 抗体 (C-Term)

PIK3C2A 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258303
发货至: 中国
  • 抗原 See all PIK3C2A 抗体
    PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))
    抗原表位
    • 9
    • 7
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    • 5
    • 2
    • 1
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    • 1
    • 1
    C-Term
    适用
    • 40
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    • 2
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    • 1
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    • 1
    • 1
    人, 小鼠
    宿主
    • 38
    • 9
    • 1
    克隆类型
    • 40
    • 8
    多克隆
    标记
    • 21
    • 5
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    • 4
    • 4
    • 1
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    This PIK3C2A antibody is un-conjugated
    应用范围
    • 39
    • 30
    • 21
    • 6
    • 2
    • 2
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    Western Blotting (WB), ELISA
    特异性
    PI 3 Kinase Class 2A Antibody detects endogenous levels of total PI 3 Kinase Class 2A.
    预测反应
    Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human PI 3 Kinase Class 2A, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product PIK3C2A Primary Antibody
  • 应用备注
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    有效期
    12 months
  • 抗原
    PIK3C2A (Phosphoinositide-3-Kinase, Class 2, alpha Polypeptide (PIK3C2A))
    别名
    PIK3C2A (PIK3C2A 产品)
    别名
    CPK antibody, PI3-K-C2(ALPHA) antibody, PI3-K-C2A antibody, cpk antibody, pi3-k-c2a antibody, Cpk-m antibody, PI3KC2 antibody, sb:cb156 antibody, si:dkey-24l11.7 antibody, wu:fc02a04 antibody, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha antibody, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha antibody, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha S homeolog antibody, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha antibody, PIK3C2A antibody, Pik3c2a antibody, pik3c2a antibody, pik3c2a.S antibody, LOC100548137 antibody
    背景

    Description: Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. Has a role in several intracellular trafficking events. Functions in insulin signaling and secretion. Required for translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane and glucose uptake in response to insulin-mediated RHOQ activation. Regulates insulin secretion through two different mechanisms: involved in glucose-induced insulin secretion downstream of insulin receptor in a pathway that involves AKT1 activation and TBC1D4/AS160 phosphorylation, and participates in the late step of insulin granule exocytosis probably in insulin granule fusion. Synthesizes PtdIns3P in response to insulin signaling. Functions in clathrin-coated endocytic vesicle formation and distribution. Regulates dynamin-independent endocytosis, probably by recruiting EEA1 to internalizing vesicles. In neurosecretory cells synthesizes PtdIns3P on large dense core vesicles. Participates in calcium induced contraction of vascular smooth muscle by regulating myosin light chain (MLC) phosphorylation through a mechanism involving Rho kinase-dependent phosphorylation of the MLCP-regulatory subunit MYPT1. May play a role in the EGF signaling cascade. May be involved in mitosis and UV-induced damage response. Required for maintenance of normal renal structure and function by supporting normal podocyte function.

    Gene: PIK3C2A

    分子量
    191 kDa
    基因ID
    5286
    UniProt
    O00443
    途径
    EGFR Signaling Pathway, Inositol Metabolic Process, Platelet-derived growth Factor Receptor Signaling
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