PIK3 gamma 抗体 (C-Term)
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- 抗原 See all PIK3 gamma (PIK3CG) 抗体
- PIK3 gamma (PIK3CG) (Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIK3 gamma antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- PIK3CG Antibody detects endogenous levels of total PIK3CG.
- 预测反应
- Pig,Sheep,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PIK3CG, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PIK3CG Primary Antibody
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anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) antibody
PIK3CG 适用: 人 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 4D3 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) antibodyPIK3CG 适用: 人, 小鼠, 猴 WB, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 6H5 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) antibodyPIK3CG 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2B1 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) (AA 1-200) antibodyPIK3CG 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) (AA 1-100) antibodyPIK3CG 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2G3 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) (AA 1-310) antibodyPIK3CG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) (C-Term) antibodyPIK3CG 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) (AA 1-100) antibodyPIK3CG 适用: 人 ELISA 宿主: 小鼠 Monoclonal 4B5D2 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) (AA 438-588), (Catalytic Subunit gamma) antibodyPIK3CG 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG) antibodyPIK3CG 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IHC: 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PIK3 gamma (PIK3CG) (Phosphoinositide-3-Kinase, Catalytic, gamma Polypeptide (PIK3CG))
- 别名
- PIK3CG (PIK3CG 产品)
- 别名
- PI3CG antibody, PI3K antibody, PI3Kgamma antibody, PIK3 antibody, Pi3k antibody, wu:fb15d07 antibody, zgc:77033 antibody, pi3k antibody, 5830428L06Rik antibody, p110gamma antibody, p120-PI3K antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma antibody, si:rp71-17i16.5 antibody, PIK3CG antibody, Pik3cg antibody, pik3cg antibody, si:rp71-17i16.5 antibody
- 背景
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Description: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
Gene: PIK3CG
- 分子量
- 120 kDa
- 基因ID
- 5294
- UniProt
- P48736
- 途径
- PI3K-Akt Signaling, RTK signaling, AMPK Signaling, TLR signaling, Inositol Metabolic Process, Hepatitis C, VEGF Signaling
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