MAP2K7 抗体 (Internal Region)
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- 抗原 See all MAP2K7 抗体
- MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MAP2K7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- MKK7 Antibody detects endogenous levels of total MKK7.
- 预测反应
- Pig,Zebrafish,Bovine,Rabbit,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human MAP2K7, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product MAP2K7 Primary Antibody
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anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) antibody
MAP2K7 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 1-250) antibodyMAP2K7 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 1-99) antibodyMAP2K7 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 2G5 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 113-388) antibodyMAP2K7 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 2-40), (N-Term) antibodyMAP2K7 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 17-160) antibodyMAP2K7 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 206-233) antibodyMAP2K7 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (pSer271), (pThr275) antibodyMAP2K7 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 325-360) antibodyMAP2K7 适用: 大鼠 WB 宿主: 兔 Polyclonal RB53023 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7) (AA 363-396) antibodyMAP2K7 适用: 人 WB 宿主: 兔 Polyclonal RB53024 unconjugated
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- 应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))
- 别名
- MAP2K7 (MAP2K7 产品)
- 别名
- MAP2K7 antibody, 2 antibody, JNKK antibody, Jnkk2 antibody, Mapkk7 antibody, Mek7 antibody, Mkk7 antibody, MAPKK7 antibody, MKK7 antibody, PRKMK7 antibody, SAPKK-4 antibody, SAPKK4 antibody, 5930412N11Rik antibody, JNKK 2 antibody, MAPKK 7 antibody, MEK 7 antibody, Prkmk7 antibody, sek2 antibody, si:ch211-254d18.2 antibody, map2k7-A antibody, mitogen-activated protein kinase kinase 7 antibody, mitogen activated protein kinase kinase 7 antibody, mitogen-activated protein kinase kinase 7 L homeolog antibody, MAP2K7 antibody, Map2k7 antibody, map2k7 antibody, map2k7.L antibody
- 背景
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Description: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Gene: MAP2K7
- 分子量
- 47 kDa
- 基因ID
- 5609
- UniProt
- O14733
- 途径
- MAPK Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
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