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PLK3 抗体 (Internal Region)

PLK3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258103
发货至: 中国
  • 抗原 See all PLK3 抗体
    PLK3 (Polo-Like Kinase 3 (PLK3))
    抗原表位
    • 8
    • 8
    • 7
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 45
    • 23
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 41
    • 2
    • 2
    克隆类型
    • 45
    多克隆
    标记
    • 23
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PLK3 antibody is un-conjugated
    应用范围
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    PLK3 Antibody detects endogenous levels of total PLK3.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human PLK3, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product PLK3 Primary Antibody
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    PLK3 (Polo-Like Kinase 3 (PLK3))
    别名
    PLK3 (PLK3 产品)
    别名
    cnk antibody, wu:fi35f10 antibody, fnk antibody, prk antibody, plx3 antibody, MGC89507 antibody, PLK2/3 antibody, NV15469 antibody, Plx3 antibody, CNK antibody, FNK antibody, PRK antibody, Cnk antibody, Fnk antibody, polo-like kinase 3 (Drosophila) antibody, polo like kinase 3 antibody, polo-like kinase 3 antibody, polo-like kinase 3 S homeolog antibody, polo-like kinase 3 L homeolog antibody, Serine/threonine-protein kinase plk-3 antibody, plk3 antibody, PLK3 antibody, LOC100118436 antibody, plk3.S antibody, plk3.L antibody, Plk3 antibody, plk-3 antibody
    背景

    Description: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1.

    Gene: PLK3

    分子量
    70 kDa
    基因ID
    1263
    UniProt
    Q9H4B4
    途径
    Regulation of long-term Neuronal Synaptic Plasticity
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