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CBLN1 抗体 (C-Term)

CBLN1 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258087
发货至: 中国
  • 抗原 See all CBLN1 抗体
    CBLN1 (Cerebellin 1 Precursor (CBLN1))
    抗原表位
    • 5
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 16
    • 15
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 16
    • 1
    克隆类型
    • 16
    • 1
    多克隆
    标记
    • 10
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CBLN1 antibody is un-conjugated
    应用范围
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    CBLN1 Antibody detects endogenous levels of total CBLN1.
    预测反应
    Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human CBLN1, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    CBLN1 (Cerebellin 1 Precursor (CBLN1))
    别名
    CBLN1 (CBLN1 产品)
    别名
    cbln1 antibody, zgc:92807 antibody, CBLN1 antibody, MGC145915 antibody, AI323299 antibody, cerebellin 3 precursor antibody, cerebellin 1 precursor antibody, cerebellin 1 precursor L homeolog antibody, cerebellin 1 precursor protein antibody, cbln3 antibody, cbln1 antibody, cbln1.L antibody, CBLN1 antibody, Cbln1 antibody
    背景

    Description: Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the matching and maintenance of pre- and post-synaptic elements at parallel fiber-Purkinje cell synapses, the establishment of the proper pattern of climbing fiber-Purkinje cell innervation, and induction of long-term depression at parallel fiber-Purkinje cell synapses. Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site through association of GRID2. NRXN1-CBLN1-GRID2 complex directly induces parallel fiber protrusions that encapsulate spines of Purkinje cells leading to accumulation of GRID2 and synaptic vesicles. Required for CBLN3 export from the endoplasmic reticulum and secretion (By similarity). NRXN1-CBLN1-GRID2 complex mediates the D-Serine-dependent long term depression signals and AMPA receptor endocytosis (PubMed:27418511).

    Gene: CBLN1

    分子量
    25 kDa
    基因ID
    869
    UniProt
    P23435
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