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- 抗原 See all CLNS1A 抗体
- CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CLNS1A antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- CLNS1A Antibody detects endogenous levels of total CLNS1A.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CLNS1A, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CLNS1A Primary Antibody
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anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) antibody
CLNS1A 适用: 人 WB, ICC, DB 宿主: 小鼠 Monoclonal 2187C2a unconjugated
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 1-237) antibodyCLNS1A 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 189-216), (C-Term) antibodyCLNS1A 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19567 unconjugated
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 148-176) antibodyCLNS1A 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB19566 unconjugated
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (C-Term) antibodyCLNS1A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (AA 138-187) antibodyCLNS1A 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, Bat, 小鸡, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (C-Term) antibodyCLNS1A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A) (C-Term) antibodyCLNS1A 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- CLNS1A (Chloride Channel, Nucleotide-Sensitive, 1A (CLNS1A))
- 别名
- CLNS1A (CLNS1A 产品)
- 别名
- CLCI antibody, CLNS1B antibody, ICln antibody, 2610036D06Rik antibody, 2610100O04Rik antibody, Clci antibody, Clcni antibody, ICLN antibody, Icln antibody, pICln antibody, clci antibody, clns1b antibody, icln antibody, pIcIn antibody, chloride nucleotide-sensitive channel 1A antibody, chloride channel, nucleotide-sensitive, 1A antibody, chloride channel, nucleotide-sensitive, 1A L homeolog antibody, CLNS1A antibody, Clns1a antibody, clns1a.L antibody, clns1a antibody
- 背景
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Description: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
Gene: CLNS1A
- 分子量
- 37 kDa
- 基因ID
- 1207
- UniProt
- P54105
- 途径
- Ribonucleoprotein Complex Subunit Organization
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