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BOK 抗体 (N-Term)

BOK 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6257961
发货至: 中国
  • 抗原 See all BOK 抗体
    BOK (BCL2-Related Ovarian Killer (BOK))
    抗原表位
    • 14
    • 11
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 44
    • 11
    • 5
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 42
    • 2
    克隆类型
    • 44
    多克隆
    标记
    • 19
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BOK antibody is un-conjugated
    应用范围
    • 27
    • 27
    • 13
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    BOK Antibody detects endogenous levels of total BOK.
    预测反应
    Pig,Bovine,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human BOK, corresponding to a region within N-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product BOK Primary Antibody
  • 应用备注
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    BOK (BCL2-Related Ovarian Killer (BOK))
    别名
    BOK (BOK 产品)
    别名
    BOK antibody, bok antibody, zgc:100979 antibody, zgc:64041 antibody, BCL2L9 antibody, BOKL antibody, Bok-BH3 antibody, AI847676 antibody, AU021146 antibody, matador antibody, mtd antibody, BOK, BCL2 family apoptosis regulator antibody, BCL2-related ovarian killer a antibody, BCL2-related ovarian killer b antibody, BCL2-related ovarian killer antibody, BOK antibody, boka antibody, bokb antibody, Bok antibody
    背景

    Description: Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release (PubMed:27076518). In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner (PubMed:15102863). Plays a role in granulosa cell apoptosis by CASP3 activation (PubMed:20673843). Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression (PubMed:19942931). May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 (PubMed:24113155).

    Gene: BOK

    分子量
    23 kDa
    基因ID
    666
    UniProt
    Q9UMX3
    途径
    Positive Regulation of Endopeptidase Activity
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