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- 抗原 See all FFAR2 抗体
- FFAR2 (Free Fatty Acid Receptor 2 (FFAR2))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FFAR2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- GPR43 Antibody detects endogenous levels of total GPR43.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GPR43, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product FFAR2 Primary Antibody
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anti-Free Fatty Acid Receptor 2 (FFAR2) (AA 41-140) antibody
FFAR2 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (AA 301-314), (C-Term), (Intracellular) antibodyFFAR2 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (AA 277-330) antibodyFFAR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (Extracellular Domain) antibodyFFAR2 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (Cytoplasmic Domain) antibodyFFAR2 适用: 人, 小鼠, 大鼠, 猴, Pig IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (AA 231-330) antibodyFFAR2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B3 unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (AA 271-320) antibodyFFAR2 适用: 人 ELISA, IHC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (AA 286-315) antibodyFFAR2 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (C-Term) antibodyFFAR2 适用: 人 IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 2 (FFAR2) (2nd Extracellular Loop), (AA 153-167) antibodyFFAR2 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- FFAR2 (Free Fatty Acid Receptor 2 (FFAR2))
- 别名
- FFAR2 (FFAR2 产品)
- 别名
- FFA2R antibody, GPR43 antibody, Gpr43 antibody, GPCR43 antibody, free fatty acid receptor 2 antibody, FFAR2 antibody, Ffar2 antibody
- 背景
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Description: G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097). Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate (PubMed:12496283, PubMed:12711604). Exhibits a SCFA-independent constitutive G protein-coupled receptor activity (PubMed:23066016).
Gene: FFAR2
- 分子量
- 37 kDa
- 基因ID
- 2867
- UniProt
- O15552
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