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CHP 抗体 (Internal Region)

CHP 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6257590
发货至: 中国
  • 抗原 See all CHP 抗体
    CHP (Calcium Binding Protein P22 (CHP))
    抗原表位
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 39
    • 15
    • 14
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 37
    • 2
    克隆类型
    • 37
    • 2
    多克隆
    标记
    • 17
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This CHP antibody is un-conjugated
    应用范围
    • 20
    • 16
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    CHP Antibody detects endogenous levels of total CHP.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human CHP, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product CHP Primary Antibody
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    CHP (Calcium Binding Protein P22 (CHP))
    别名
    CHP1 (CHP 产品)
    别名
    CHP antibody, SLC9A1BP antibody, Sid470p antibody, p22 antibody, p24 antibody, 1500003O03Rik antibody, AA960066 antibody, AI046351 antibody, Cahp antibody, Chp antibody, Wrch2 antibody, chp antibody, si:dkey-41n20.1 antibody, wu:fc69b04 antibody, zgc:63904 antibody, wu:fi19e07 antibody, zgc:55363 antibody, calcineurin like EF-hand protein 1 antibody, calcineurin-like EF hand protein 1 antibody, calcineurin-like EF-hand protein 1 antibody, calcineurin-like EF-hand protein 2 antibody, calcineurin-like EF-hand protein 1 L homeolog antibody, CHP1 antibody, Chp1 antibody, chp1 antibody, chp2 antibody, chp1.L antibody
    背景

    Description: Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na+/H+ exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell  pH regulation by controlling plasma membrane-type Na+/H+ exchange activity. Affects the  pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic  pH . Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na+/H+ exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

    Gene: CHP1

    分子量
    22 kDa
    基因ID
    11261
    UniProt
    Q99653
    途径
    Proton Transport, Regulation of Carbohydrate Metabolic Process, VEGF Signaling
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