THO Complex 4 抗体 (Internal Region)
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- 抗原 See all THO Complex 4 (THOC4) 抗体
- THO Complex 4 (THOC4)
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This THO Complex 4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- THOC4 Antibody detects endogenous levels of total THOC4.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human THOC4, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product THOC4 Primary Antibody
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anti-THO Complex 4 (THOC4) antibody
THOC4 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 4 (THOC4) antibodyTHOC4 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 4 (THOC4) antibodyTHOC4 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-THO Complex 4 (THOC4) (AA 106-193) antibodyTHOC4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G8 unconjugated
anti-THO Complex 4 (THOC4) (AA 186-240) antibodyTHOC4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 4 (THOC4) antibodyTHOC4 适用: 人, 非洲爪蟾 WB, ELISA, IF, IP, IHC (p), ICC, ChIP, EM, FACS 宿主: 小鼠 Monoclonal 11G5 unconjugated
anti-THO Complex 4 (THOC4) antibodyTHOC4 适用: 人, 小鼠, 非洲爪蟾 WB, ELISA, IF, IP, IHC (p), ICC, ChIP, EM, FACS 宿主: 小鼠 Monoclonal 11G5 unconjugated
anti-THO Complex 4 (THOC4) (AA 58-107) antibodyTHOC4 适用: 人, 小鼠, 大鼠, 非洲爪蟾, Cow, 斑马鱼, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 4 (THOC4) (N-Term) antibodyTHOC4 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-THO Complex 4 (THOC4) (N-Term) antibodyTHOC4 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- THO Complex 4 (THOC4)
- 别名
- ALYREF (THOC4 产品)
- 别名
- THOC4 antibody, Aly antibody, ALY antibody, ALY/REF antibody, BEF antibody, REF antibody, tho4 antibody, thoc4 antibody, zgc:171753 antibody, Tho4-A antibody, alyref-a antibody, thoc4-a antibody, REF1 antibody, Refbp1 antibody, Thoc4 antibody, Tho4 antibody, Aly/REF export factor antibody, THO complex 4 antibody, Aly/REF export factor L homeolog antibody, ALYREF antibody, Thoc4 antibody, alyref antibody, alyref.L antibody, Alyref antibody
- 背景
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Description: Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production, ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA, proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability.
Gene: ALYREF
- 分子量
- 27 kDa
- 基因ID
- 10189
- UniProt
- Q86V81
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