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- 抗原 See all PKC eta (PRKCH) 抗体
- PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PKC eta antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- PRKCH Antibody detects endogenous levels of total PRKCH.
- 预测反应
- Pig,Bovine,Horse,Sheep,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PRKCH, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PRKCH Primary Antibody
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anti-Protein Kinase C, eta (PRKCH) (AA 1-678) antibody
PRKCH 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 1-100) antibodyPRKCH 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 1-683) antibodyPRKCH 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 210-239), (N-Term) antibodyPRKCH 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 355-614) antibodyPRKCH 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 1-683) antibodyPRKCH 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 517-566) antibodyPRKCH 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 兔, 马, 斑马鱼, 犬, Pig, 猴, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 35-84) antibodyPRKCH 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 斑马鱼, 犬, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (C-Term) antibodyPRKCH 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, eta (PRKCH) (AA 30-389) antibodyPRKCH 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))
- 别名
- PRKCH (PRKCH 产品)
- 别名
- PKC-L antibody, PKCL antibody, PRKCL antibody, nPKC-eta antibody, Pkch antibody, pkc-eta antibody, PRKCH antibody, prkch antibody, si:ch211-212g7.5 antibody, zgc:172124 antibody, protein kinase C eta antibody, protein kinase C, eta antibody, protein kinase C eta L homeolog antibody, protein kinase C, eta, b antibody, protein kinase C, eta, a antibody, protein kinase C epsilon antibody, PRKCH antibody, Prkch antibody, prkch.L antibody, prkchb antibody, prkcha antibody, prkch antibody, PRKCE antibody
- 背景
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Description: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.
Gene: PRKCH
- 分子量
- 78 kDa
- 基因ID
- 5583
- UniProt
- P24723
- 途径
- Myometrial Relaxation and Contraction, Thromboxane A2 Receptor Signaling
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