Casein Kinase 1 delta 抗体 (Internal Region)
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- 抗原 See all Casein Kinase 1 delta (CSNK1D) 抗体
- Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Casein Kinase 1 delta antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Casein Kinase 1 delta Antibody detects endogenous levels of total Casein Kinase 1 delta.
- 预测反应
- Pig,Bovine,Horse,Sheep,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Casein Kinase 1 delta, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CSNK1D Primary Antibody
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- Casein Kinase 1 delta (CSNK1D) (Casein Kinase 1, delta (CSNK1D))
- 别名
- CSNK1D (CSNK1D 产品)
- 别名
- ASPS antibody, CKIdelta antibody, FASPS2 antibody, HCKID antibody, 1200006A05Rik antibody, AA409348 antibody, D930010H05Rik antibody, CKI-delta antibody, CKId antibody, csnk1d antibody, wu:fb69b03 antibody, wu:fj97a05 antibody, zgc:77627 antibody, CSNK1D antibody, ckIdelta antibody, Csnk1d antibody, csnk1dl antibody, wu:fb50c04 antibody, zgc:63971 antibody, casein kinase 1 delta antibody, casein kinase 1, delta antibody, casein kinase 1, delta b antibody, casein kinase 1 delta S homeolog antibody, casein kinase 1, delta a antibody, CSNK1D antibody, Csnk1d antibody, csnk1d antibody, csnk1db antibody, Bm1_37175 antibody, csnk1d.S antibody, csnk1da antibody
- 背景
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Description: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate.
Gene: CSNK1D
- 分子量
- 47 kDa
- 基因ID
- 1453
- UniProt
- P48730
- 途径
- Hedgehog Signaling, M Phase
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