CSNK2A2 抗体 (N-Term)
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- 抗原 See all CSNK2A2 抗体
- CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CSNK2A2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- CSNK2A2 Antibody detects endogenous levels of total CSNK2A2.
- 预测反应
- Pig,Bovine,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human CSNK2A2, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product CSNK2A2 Primary Antibody
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- 应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- CSNK2A2 (Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2))
- 别名
- CSNK2A2 (CSNK2A2 产品)
- 别名
- CK2A2 antibody, CSNK2A1 antibody, 1110035J23Rik antibody, C77789 antibody, CK2 antibody, CSNK2A2 antibody, ck2a2 antibody, csnk2a1 antibody, wu:fi09h12 antibody, casein kinase 2 alpha 2 antibody, casein kinase 2, alpha prime polypeptide antibody, casein kinase 2 alpha 2 L homeolog antibody, casein kinase 2, alpha prime polypeptide a antibody, CSNK2A2 antibody, Csnk2a2 antibody, csnk2a2.L antibody, csnk2a2 antibody, csnk2a2a antibody
- 背景
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Description: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
Gene: CSNK2A2
- 分子量
- 41 kDa
- 基因ID
- 1459
- UniProt
- P19784
- 途径
- SARS-CoV-2 Protein Interactome
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