PRKACB 抗体 (C-Term)
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- 抗原 See all PRKACB 抗体
- PRKACB (Protein Kinase, CAMP Dependent, Catalytic, beta (PRKACB))
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抗原表位
- C-Term
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PRKACB antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- PKA beta Antibody detects endogenous levels of total PKA beta.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PKA beta, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PRKACB Primary Antibody
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PRKACB (Protein Kinase, CAMP Dependent, Catalytic, beta (PRKACB))
- 别名
- PRKACB (PRKACB 产品)
- 别名
- PKACB antibody, XPKAbeta antibody, kin-1 antibody, pkacb antibody, prkacba antibody, PRKACB antibody, prkacb antibody, wu:fz54b03 antibody, zgc:110804 antibody, Pkacb antibody, protein kinase cAMP-activated catalytic subunit beta antibody, protein kinase cAMP-activated catalytic subunit beta S homeolog antibody, protein kinase, cAMP-dependent, catalytic, beta antibody, protein kinase, cAMP-dependent, catalytic, beta b antibody, protein kinase, cAMP dependent, catalytic, beta antibody, PRKACB antibody, prkacb.S antibody, prkacb antibody, Prkacb antibody, prkacbb antibody
- 背景
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Description: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142).
Gene: PRKACB
- 分子量
- 53 kDa
- 基因ID
- 5567
- UniProt
- P22694
- 途径
- AMPK Signaling, Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Lipid Metabolism
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