IGF1R 抗体 (pTyr1161)
-
- 抗原 See all IGF1R 抗体
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
-
抗原表位
- pTyr1161
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This IGF1R antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)
- 特异性
- Phospho-IGF1R/Insulin Receptor (Tyr1161) Antibody detects endogenous levels of IGF1R/Insulin Receptor only when phosphorylated at Tyrosine 1161.
- 预测反应
- Bovine,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human IGF1R/Insulin Receptor around the phosphorylation site of Tyr1161.
- 亚型
- IgG
- Top Product
- Discover our top product IGF1R Primary Antibody
-
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 251-350) antibody
IGF1R 适用: 人, 小鼠, 大鼠, 犬 FACS 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1346) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr1165), (pTyr1166) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 51-77) antibodyIGF1R 适用: 人 WB, ELISA, IHC, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 1335-1366), (C-Term) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB01458 unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (C-Term) antibodyIGF1R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 660-760) antibodyIGF1R 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (pTyr980) antibodyIGF1R 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (Tyr1346) antibodyIGF1R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Insulin-Like Growth Factor 1 Receptor (IGF1R) (AA 763-955) antibodyIGF1R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IP, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
-
- 抗原
- IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))
- 别名
- IGF1R,INSR (IGF1R 产品)
- 背景
-
Description: Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R.
Gene: IGF1R
- 分子量
- 90,155kDa
- 基因ID
- 3480, 3643
- UniProt
- P08069, P06213
- 途径
- RTK signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy
-
