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Ret Proto-Oncogene 抗体 (pTyr1062)

Name: Ret Proto-Oncogene 抗体 (pTyr1062)
SKU: ABIN6256615
Availability: OutOfStock

RET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Ret phosphorylation expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (Ret Proto-Oncogene 抗体 (pTyr1062))

IF/ICC

Western blot analysis of Phospho-Ret (Tyr1062) expression in various lysates (Ret Proto-Oncogene 抗体 (pTyr1062))

3 images

产品编号 ABIN6256615

发货至: 中国

Datasheet as PDF

抗原 See all Ret Proto-Oncogene (RET) 抗体

Ret Proto-Oncogene (RET)
抗原表位
25

19

15

15

15

11

9

9

8

8

8

7

6

6

4

4

4

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr1062
适用
159

101

81

5

3

2

2

2

2

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
182

22

2

2

1

1
兔
Compatible Secondaries
克隆类型
180

30
多克隆
标记
87

14

10

9

6

5

5

5

5

5

5

5

5

5

5

5

4

4

4

4

4

4

4

1
This Ret Proto-Oncogene antibody is un-conjugated
应用范围
168

82

66

65

40

29

17

16

13

8

4

3

2

1

1

1

1

1

1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-Ret (Tyr1062) Antibody detects endogenous levels of Ret only when phosphorylated at Tyrosine 1062.

预测反应

Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Xenopus

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human Ret around the phosphorylation site of Tyr1062.

亚型

IgG

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RET 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal RET-2795 unconjugated

anti-Ret Proto-Oncogene (RET) (AA 1-1072) antibody
RET 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Ret Proto-Oncogene (RET) (AA 702-848) antibody
RET 适用: 人 ELISA, Coat 宿主: 小鼠 Monoclonal RET-2663 unconjugated

anti-Ret Proto-Oncogene (RET) (AA 361-458) antibody
RET 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 1A5 unconjugated

anti-Ret Proto-Oncogene (RET) (C-Term) antibody
RET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ret Proto-Oncogene (RET) (AA 29-300) antibody
RET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Ret Proto-Oncogene (RET) (AA 541-553), (Extracellular), (N-Term) antibody
RET 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, LCI 宿主: 兔 Polyclonal unconjugated

anti-Ret Proto-Oncogene (RET) (AA 1001-1114) antibody
RET 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated

anti-Ret Proto-Oncogene (RET) (pTyr905) antibody
RET 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ret Proto-Oncogene (RET) (AA 29-300) antibody
RET 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

Ret Proto-Oncogene (RET)

别名

RET (RET 产品)

别名

c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody

背景

Description: Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. Regulates both cell death/survival balance and positional information. Required for the molecular mechanisms orchestration during intestine organogenesis, involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Modulates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis through a mechanism that requires receptor intracellular caspase cleavage. Acts as a dependence receptor, in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regulates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. Regulates nociceptor survival and size. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers, these diseases are characterized by aberrant integrins-regulated cell migration. Mediates, through interaction with GDF15-receptor GFRAL, GDF15-induced cell-signaling in the brainstem which induces inhibition of food-intake. Activates MAPK- and AKT-signaling pathways (PubMed:28846097, PubMed:28953886, PubMed:28846099). Isoform 1 in complex with GFRAL induces higher activation of MAPK-signaling pathway than isoform 2 in complex with GFRAL (PubMed:28846099).
Gene: RET

分子量

175kDa

基因ID

5979

UniProt

P07949

途径

RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation