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SP1 抗体 (pThr453)

SP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of SP1 phosphorylation expression in A549 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Mouse testis tissue sections by IHC-P. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Mouse lung tissue sections by IHC-P. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Human lung cancer tissue sections by IHC-P. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Human kidney tissue sections by IHC-P. (SP1 抗体 (pThr453))

ABIN6267333 staining HeLa cells by ICC/IF. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Human lung cancer tissue sections by IHC-P. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Mouse lung tissue sections by IHC-P. (SP1 抗体 (pThr453))

Western blot analysis of Phospho-SP1 (Thr453) expression in various lysates (SP1 抗体 (pThr453))

ABIN6267333 staining A549 by IF/ICC. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Mouse testis tissue sections by IHC-P. (SP1 抗体 (pThr453))

ABIN6267333 at 1/200 staining Rat lung tissue sections by IHC-P. (SP1 抗体 (pThr453))

12 images

产品编号 ABIN6256566

发货至: 中国

Datasheet as PDF

抗原 See all SP1 抗体

SP1 (Sp1 Transcription Factor (SP1))
抗原表位
20

15

12

7

7

7

6

4

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pThr453
适用
97

66

45

11

8

7

6

5

5

5

4

2

2

2

1
人, 小鼠, 大鼠
宿主
99

13

3
兔
Compatible Secondaries
克隆类型
94

21
多克隆
标记
70

6

3

3

3

3

3

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1
This SP1 antibody is un-conjugated
应用范围
93

48

47

39

21

15

14

14

13

7

3

3

3

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-SP1 (Thr453) Antibody detects endogenous levels of SP1 only when phosphorylated at Threonine 453.

预测反应

Pig,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human SP1 around the phosphorylation site of Thr453.

亚型

IgG

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SP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4B11 unconjugated

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SP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4H6 unconjugated

anti-Sp1 Transcription Factor (SP1) antibody
SP1 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Monoclonal unconjugated

anti-Sp1 Transcription Factor (SP1) (C-Term) antibody
SP1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Sp1 Transcription Factor (SP1) (pThr739) antibody
SP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Sp1 Transcription Factor (SP1) (AA 89-199) antibody
SP1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4H6 unconjugated

anti-Sp1 Transcription Factor (SP1) (AA 420-620) antibody
SP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Sp1 Transcription Factor (SP1) (AA 677-707), (C-Term) antibody
SP1 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB17350 unconjugated

anti-Sp1 Transcription Factor (SP1) (AA 677-707) antibody
SP1 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

SP1 (Sp1 Transcription Factor (SP1))

别名

SP1 (SP1 产品)

别名

fc18h09 antibody, zgc:85950 antibody, wu:fc18h09 antibody, SP1 antibody, 1110003E12Rik antibody, AA450830 antibody, AI845540 antibody, Sp1-1 antibody, sp1 transcription factor antibody, Sp1 transcription factor antibody, Sp1 transcription factor L homeolog antibody, trans-acting transcription factor 1 antibody, sp1 antibody, SP1 antibody, Sp1 antibody, sp1.L antibody

背景

Description: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1 (PubMed:10391891, PubMed:11371615, PubMed:11904305, PubMed:14593115, PubMed:16377629, PubMed:16478997, PubMed:16943418, PubMed:17049555, PubMed:18171990, PubMed:18199680, PubMed:18239466, PubMed:18513490, PubMed:18619531, PubMed:19193796, PubMed:20091743, PubMed:21798247). Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112 (By similarity).
Gene: SP1

分子量

90kDa

基因ID

6667

UniProt

P08047

途径

Regulation of Lipid Metabolism by PPARalpha, Myometrial Relaxation and Contraction

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