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HDAC3 抗体 (pSer424)

Name: HDAC3 抗体 (pSer424)
SKU: ABIN6256332
Availability: OutOfStock

HDAC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Phospho-HDAC3 (Ser424) Antibody expression in mouse lung and mouse brain tissues lysates. (HDAC3 抗体 (pSer424))

ABIN6267233 staining A549 cells by ICC/IF. (HDAC3 抗体 (pSer424))

IF/ICC

ABIN6267233 at 1/200 staining human liver cancer tissue sections by IHC-P. (HDAC3 抗体 (pSer424))

IHC

Western blot analysis of HDAC3 phosphorylation expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (HDAC3 抗体 (pSer424))

ABIN6267233 at 1/50 staining human liver cancer tissue sections by IHC-P. (HDAC3 抗体 (pSer424))

IHC

Western blot analysis of extracts of rat spleen tissue lysates,using Phospho-HDAC3 (Ser424) Antibody. (HDAC3 抗体 (pSer424))

Western blot analysis of extracts from rat brain, mouse brain, using Phospho-HDAC3 (Ser424) Antibody. (HDAC3 抗体 (pSer424))

Western blot analysis of extracts from various samples, using Phospho-HDAC3 (Ser424) Antibody. (HDAC3 抗体 (pSer424))

9 images

产品编号 ABIN6256332

发货至: 中国

Datasheet as PDF

抗原 See all HDAC3 抗体

HDAC3 (Histone Deacetylase 3 (HDAC3))
抗原表位
23

22

16

10

8

5

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer424
适用
116

70

67

8

7

6

6

5

4

4

3

2

2

1

1

1
人, 小鼠, 大鼠
宿主
89

26

1
兔
Compatible Secondaries
克隆类型
92

24
多克隆
标记
61

6

6

5

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2
This HDAC3 antibody is un-conjugated
应用范围
95

51

36

27

26

24

16

16

12

7

6

6

4

2

2

2

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-HDAC3 (Ser424) Antibody detects endogenous levels of HDAC3 only when phosphorylated at Serine 424.

预测反应

Pig,Zebrafish,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human HDAC3 around the phosphorylation site of Ser424.

亚型

IgG

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anti-Histone Deacetylase 3 (HDAC3) (AA 31-130) antibody
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anti-Histone Deacetylase 3 (HDAC3) (AA 224-428) antibody
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应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

HDAC3 (Histone Deacetylase 3 (HDAC3))

别名

HDAC3 (HDAC3 产品)

别名

CG2128 antibody, DHDAC3 antibody, DmHDAC3 antibody, Dmel\\CG2128 antibody, Dromel_CG2128_FBtr0078767_hdac3_mORF antibody, HDAC antibody, HDAC3 antibody, Hdac 3 antibody, dHDAC3 antibody, dmHDA402 antibody, hdac3 antibody, HDm antibody, hd3 antibody, RPD3 antibody, XRpd3 antibody, rpd3-2 antibody, HD3 antibody, RPD3-2 antibody, AW537363 antibody, zgc:55927 antibody, Histone deacetylase 3 antibody, histone deacetylase 3 antibody, histone deacetylase 3 S homeolog antibody, HDAC3 antibody, hdac3 antibody, CNL05260 antibody, Hdac3 antibody, hdac3.S antibody

背景

Description: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1, increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289). Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI3K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803).
Gene: HDAC3

分子量

48kDa

基因ID

8841

UniProt

O15379

途径

Neurotrophin Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development