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p53 抗体 (pSer15)

TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of p53 phosphorylation expression in HU treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining mouse lung tissue sections by IHC-P. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining rat spleen cancer tissue sections by IHC-P. (p53 抗体 (pSer15))

ABIN6267289 staining MDA-MB-435 by IF/ICC. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining human gastric tissue sections by IHC-P. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining human liver cancer tissue sections by IHC-P. (p53 抗体 (pSer15))

ABIN6267289 staining MDA-MB-435 by IF/ICC. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining mouse gastric tissue sections by IHC-P. (p53 抗体 (pSer15))

Western blot analysis of Phospho-p53 (Ser15) expression in various lysates (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining rat liver cancer tissue sections by IHC-P. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining mouse pancreas tissue sections by IHC-P. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining human skin tissue sections by IHC-P. (p53 抗体 (pSer15))

ABIN6267289 at 1/100 staining rat lung cancer tissue sections by IHC-P. (p53 抗体 (pSer15))

13 images

产品编号 ABIN6256151

发货至: 中国

Datasheet as PDF

抗原 See all p53 (TP53) 抗体

p53 (TP53) (Tumor Protein P53 (TP53))
抗原表位
51

45

42

35

35

29

28

26

23

22

20

19

19

18

18

17

16

16

14

13

10

10

9

8

8

8

8

7

7

7

7

6

6

6

6

5

5

5

5

4

4

4

4

4

4

4

4

3

3

3
pSer15
适用
890

263

221

114

44

34

31

18

9

8

7

6

4

3

3

2

2

2

2

2

1

1

1

1
人, 小鼠, 大鼠
宿主
688

218

6

2

1
兔
Compatible Secondaries
克隆类型
642

272

1
多克隆
标记
485

46

38

25

21

17

16

16

16

16

16

14

13

13

13

13

13

13

13

13

13

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
This p53 antibody is un-conjugated
应用范围
697

333

245

217

193

143

124

119

115

61

53

32

18

17

13

13

12

9

9

8

6

4

3

2

2

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

特异性

Phospho-p53 (Ser15) Antibody detects endogenous levels of p53 only when phosphorylated at Serine 15.

预测反应

Pig,Bovine,Sheep,Rabbit

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human p53 around the phosphorylation site of Ser15.

亚型

IgG

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TP53 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 2C3 unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 2C11 unconjugated

anti-Tumor Protein P53 (TP53) (pSer20) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:1000, IP 1:100-1:500, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

p53 (TP53) (Tumor Protein P53 (TP53))

别名

TP53 (TP53 产品)

别名

BCC7 antibody, LFS1 antibody, P53 antibody, TRP53 antibody, p53 antibody, Trp53 antibody, brp53 antibody, drp53 antibody, etID22686.5 antibody, fb40d06 antibody, wu:fb40d06 antibody, zgc:111919 antibody, Tp53 antibody, bbl antibody, bfy antibody, bhy antibody, p44 antibody, tp53 antibody, Xp53 antibody, TP53 antibody, tumor protein p53 antibody, cellular tumor antigen p53 antibody, transformation related protein 53 antibody, tumor protein p53 L homeolog antibody, TP53 antibody, CpipJ_CPIJ002758 antibody, Tp53 antibody, tp53 antibody, Trp53 antibody, tp53.L antibody

背景

Description: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Gene: TP53

分子量

53kDa

基因ID

7157

UniProt

P04637

途径

p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect

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