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KIT 抗体 (pTyr703)

KIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Phospho-KIT (Tyr703) expression in various lysates (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Rat kidney tissue sections by IHC-P. (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Human heart tissue sections by IHC-P. (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Mouse testis tissue sections by IHC-P. (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Mouse liver tissue sections by IHC-P. (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Rat lung tissue sections by IHC-P. (KIT 抗体 (pTyr703))

Western blot analysis of KIT phosphorylation expression in EGF treated HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (KIT 抗体 (pTyr703))

ABIN6267364 staining H526 cells treated with SCF by ICC/IF. (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Human heart tissue sections by IHC-P. (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Mouse intestinal tissue sections by IHC-P. (KIT 抗体 (pTyr703))

ABIN6267364 at 1/200 staining Mouse testis tissue sections by IHC-P. (KIT 抗体 (pTyr703))

11 images

产品编号 ABIN6255994

发货至: 中国

Datasheet as PDF

抗原 See all KIT 抗体

KIT (Mast/stem Cell Growth Factor Receptor (KIT))
抗原表位
56

54

34

33

23

23

23

19

16

16

16

16

16

16

14

13

12

12

12

11

10

8

8

8

8

8

8

7

7

7

7

7

7

7

7

7

7

7

7

7

7

7

7

7

7

7

6

6

6

6
pTyr703
适用
659

221

62

29

27

25

16

12

5

4

2

2

1
人, 小鼠, 大鼠
宿主
595

98

31

2

1
兔
Compatible Secondaries
克隆类型
588

139

1
多克隆
标记
219

78

74

72

59

59

11

10

10

10

10

10

10

10

10

10

10

5

4

4

4

4

4

4

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
This KIT antibody is un-conjugated
应用范围
415

385

280

147

91

91

61

47

44

42

30

23

10

6

6

6

2

2

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-c-Kit (Tyr703) Antibody detects endogenous levels of c-Kit only when phosphorylated at Tyrosine 703.

预测反应

Pig,Bovine,Horse,Rabbit,Dog,Chicken

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human c-Kit around the phosphorylation site of Tyr703.

亚型

IgG

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anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 350-440) antibody
KIT 适用: 人, 小鼠, 大鼠 ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 321-520) antibody
KIT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 343-527) antibody
KIT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (pTyr721) antibody
KIT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (Internal Region) antibody
Verified KIT 适用: 人 WB, ELISA, FACS, IHC, IF 宿主: 山羊 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 546-976) antibody
KIT 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E3 unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 25-295) antibody
KIT 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) antibody (FITC)
KIT 适用: 人, Cow, Non-Human Primate FACS 宿主: 小鼠 Monoclonal 104D2 FITC

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 26-285) antibody
KIT 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Mast/stem Cell Growth Factor Receptor (KIT) (AA 106-135) antibody
KIT 适用: 人, 小鼠 WB, ELISA, FACS, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

KIT (Mast/stem Cell Growth Factor Receptor (KIT))

别名

KIT (KIT 产品)

别名

C-Kit antibody, CD117 antibody, PBT antibody, SCFR antibody, Bs antibody, Fdc antibody, Gsfsco1 antibody, Gsfsco5 antibody, Gsfsow3 antibody, SCO1 antibody, SCO5 antibody, SOW3 antibody, Ssm antibody, Tr-kit antibody, W antibody, c-KIT antibody, c-kit antibody, MGF antibody, KIT antibody, C-KIT antibody, kit antibody, receptor antibody, sparse antibody, Xkl-1 antibody, kit-a antibody, kit-b antibody, kl1-A antibody, krk1 antibody, pbt antibody, scfr antibody, KIT proto-oncogene receptor tyrosine kinase antibody, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a antibody, KIT proto-oncogene receptor tyrosine kinase S homeolog antibody, KIT antibody, Kit antibody, kita antibody, kit antibody, kit.S antibody

背景

Description: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Gene: KIT

分子量

145kDa

基因ID

3815

UniProt

P10721

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity

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