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c-MET 抗体 (pTyr1349)

Name: c-MET 抗体 (pTyr1349)
SKU: ABIN6255803
Availability: OutOfStock

MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Phospho-Met (Tyr1349) expression in various lysates (c-MET 抗体 (pTyr1349))

IF/ICC

Western blot analysis of Met phosphorylation expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (c-MET 抗体 (pTyr1349))

3 images

产品编号 ABIN6255803

发货至: 中国

Datasheet as PDF

抗原 See all c-MET (MET) 抗体

c-MET (MET) (Met Proto-Oncogene (MET))
抗原表位
42

28

28

27

12

11

8

7

7

7

6

5

4

4

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr1349
适用
228

132

101

6

6

5

4

4

2

2

2

1

1

1

1
人, 小鼠, 大鼠
宿主
200

38

3

2
兔
Compatible Secondaries
克隆类型
196

47
多克隆
标记
126

19

11

11

7

7

7

7

7

7

6

6

2

2

2

2

2

2

2

2

2

2

2
This c-MET antibody is un-conjugated
应用范围
160

101

43

28

26

19

15

14

11

9

8

5

4

4

1

1

1
Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-c-Met (Tyr1349) Antibody detects endogenous levels of c-Met only when phosphorylated at Tyrosine 1349.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human c-Met around the phosphorylation site of Tyr1349.

亚型

IgG

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应用备注

WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

c-MET (MET) (Met Proto-Oncogene (MET))

别名

MET (MET 产品)

别名

AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody

背景

Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).
Gene: MET

分子量

145kDa

基因ID

4233

UniProt

P08581

途径

RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor