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ErbB2/Her2 抗体 (pTyr1112)

ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of HER2 phosphorylation expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining rat testicular tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining mouse spleen tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining rat spleen tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining mouse testicular tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining human TB tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining human appendiceal tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining mouse kidney tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 staining MDA-MB-231 by IF/ICC. (ErbB2/Her2 抗体 (pTyr1112))

ABIN6267285 at 1/100 staining human liver tissue sections by IHC-P. (ErbB2/Her2 抗体 (pTyr1112))

10 images

产品编号 ABIN6255774

发货至: 中国

Datasheet as PDF

抗原 See all ErbB2/Her2 抗体

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
抗原表位
31

29

29

29

26

26

22

21

16

15

13

13

10

10

9

9

9

9

9

8

8

8

7

7

7

7

7

7

7

7

7

7

6

6

5

5

5

3

3

3

3

3

3

3

2

2

2

2

2

2
pTyr1112
适用
510

187

165

32

8

5

3

3

3

2

1

1

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
409

147

10

5

3

3
兔
Compatible Secondaries
克隆类型
415

159

2
多克隆
标记
266

45

36

28

23

21

9

9

9

9

9

9

8

8

8

8

8

8

8

8

8

7

7

3

3

3

3

3

3
This ErbB2/Her2 antibody is un-conjugated
应用范围
291

228

139

93

92

92

87

80

60

48

29

19

12

9

8

7

5

4

3

3

2

1

1

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-HER2/ErbB2 (Tyr1112) Antibody detects endogenous levels of HER2/ErbB2 only when phosphorylated at Tyrosine 1112.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human HER2/ErbB2 around the phosphorylation site of Tyr1112.

亚型

IgG

Top Product

Discover our top product ErbB2/Her2 Primary Antibody
anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 23-372) antibody
ErbB2/Her2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠, 犬, 猴, 马, Pig, Cow, 兔, Hamster, Avian, Cat, 小鸡, 驴, 山羊, 豚鼠, 绵羊 WB 宿主: 山羊 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibody
ErbB2/Her2 适用: 人 WB, ELISA, IF, IHC (p), PLA 宿主: 小鼠 Monoclonal 3B1 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr1248) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (pTyr877) antibody
ErbB2/Her2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (C-Term) antibody
ErbB2/Her2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERBB2-3078 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 311-462) antibody
ErbB2/Her2 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal ERBB2-2452 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (AA 22-121) antibody
ErbB2/Her2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4E1 unconjugated

anti-Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2) (Extracellular Domain) antibody
ErbB2/Her2 适用: 人 ELISA, IF, FACS, Coat 宿主: 小鼠 Monoclonal HRB2-282 unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

别名

ERBB2 (ErbB2/Her2 产品)

别名

CD340 antibody, HER-2 antibody, HER-2/neu antibody, HER2 antibody, MLN 19 antibody, NEU antibody, NGL antibody, TKR1 antibody, Erbb-2 antibody, Neu antibody, c-erbB2 antibody, c-neu antibody, mKIAA3023 antibody, wu:fv70f10 antibody, zgc:63601 antibody, erb2 antibody, erb-b2 receptor tyrosine kinase 2 antibody, ERBB2 antibody, Erbb2 antibody, erbb2 antibody

背景

Description: Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Gene: ERBB2

分子量

150kDa

基因ID

2064

UniProt

P04626

途径

RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development

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