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MAP3K8 抗体 (pThr290)

MAP3K8 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6255657
发货至: 中国
  • 抗原 See all MAP3K8 抗体
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    抗原表位
    • 18
    • 12
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    pThr290
    适用
    • 86
    • 40
    • 38
    • 7
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 85
    • 1
    克隆类型
    • 85
    • 1
    多克隆
    标记
    • 37
    • 8
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    This MAP3K8 antibody is un-conjugated
    应用范围
    • 54
    • 39
    • 28
    • 17
    • 7
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-MAP3K8/COT (Thr290) Antibody detects endogenous levels of MAP3K8/COT only when phosphorylated at Threonine 290.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human MAP3K8/COT around the phosphorylation site of Thr290.
    亚型
    IgG
    Top Product
    Discover our top product MAP3K8 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    MAP3K8 (Mitogen-Activated Protein Kinase Kinase Kinase 8 (MAP3K8))
    别名
    MAP3K8 (MAP3K8 产品)
    别名
    MAP3K8 antibody, COT antibody, EST antibody, ESTF antibody, MEKK8 antibody, TPL2 antibody, Tpl-2 antibody, c-COT antibody, Cot antibody, Cot/Tpl2 antibody, Est antibody, Estf antibody, Tpl2 antibody, D17TPL2 antibody, mitogen-activated protein kinase kinase kinase 8 antibody, MAP3K8 antibody, map3k8 antibody, Map3k8 antibody
    背景

    Description: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant.

    Gene: MAP3K8

    分子量
    60kDa
    基因ID
    1326
    UniProt
    P41279
    途径
    PI3K-Akt Signaling, TCR Signaling
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