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RPA2 抗体 (pThr21)

RPA2 适用: 人, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6255629
发货至: 中国
  • 抗原 See all RPA2 抗体
    RPA2 (Replication Protein A2, 32kDa (RPA2))
    抗原表位
    • 35
    • 15
    • 8
    • 5
    • 5
    • 5
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    • 2
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    • 1
    • 1
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    pThr21
    适用
    • 99
    • 73
    • 48
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 112
    • 18
    • 2
    • 1
    克隆类型
    • 104
    • 29
    多克隆
    标记
    • 75
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This RPA2 antibody is un-conjugated
    应用范围
    • 105
    • 39
    • 38
    • 28
    • 26
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    • 23
    • 19
    • 9
    • 8
    • 6
    • 5
    • 4
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    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-RPA32/RPA2 (Thr21) Antibody detects endogenous levels of RPA32/RPA2 only when phosphorylated at Threonine 21.
    预测反应
    Pig,Zebrafish,Bovine,Sheep,Dog,Xenopus
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human RPA32/RPA2 around the phosphorylation site of Thr21.
    亚型
    IgG
    Top Product
    Discover our top product RPA2 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    RPA2 (Replication Protein A2, 32kDa (RPA2))
    别名
    RPA2 (RPA2 产品)
    别名
    REPA2 antibody, RPA32 antibody, 153194_at antibody, CG9273 antibody, Dmel\\CG9273 antibody, dRPA2 antibody, rpa antibody, zgc:109822 antibody, ik:tdsubc_2g1 antibody, xx:tdsubc_2g1 antibody, repa2 antibody, rpa32 antibody, RPA2 antibody, GB13976 antibody, LOC100230445 antibody, AA409079 antibody, AI325195 antibody, AU020965 antibody, RPA34 antibody, Rf-A2 antibody, replication protein A2 antibody, Replication protein A2 antibody, replication protein A2, 32kDa antibody, replication protein A 32 kDa subunit antibody, RPA2 antibody, Rpa2 antibody, rpa2 antibody, LOC725418 antibody, RPA2_2 antibody
    背景

    Description: As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

    Gene: RPA2

    分子量
    35kDa
    基因ID
    6118
    UniProt
    P15927
    途径
    Telomere Maintenance, DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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