Dematin 抗体 (pSer403)
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- 抗原 See all Dematin (EPB49) 抗体
- Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))
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抗原表位
- pSer403
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Dematin antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Phospho-Dematin (Ser403) Antibody detects endogenous levels of Dematin only when phosphorylated at Ser403.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human Dematin around the phosphorylation site of Ser403.
- 亚型
- IgG
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anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (C-Term) antibody
EPB49 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) antibodyEPB49 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (AA 1-383) antibodyEPB49 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (C-Term) antibodyEPB49 适用: 人, 小鼠, Cow WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (AA 356-405) antibodyEPB49 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (Ser345) antibodyEPB49 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (AA 142-191) antibodyEPB49 适用: 人, Cow, 马, 犬, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49) (AA 356-405), (pSer403) antibodyEPB49 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- Dematin (EPB49) (erythrocyte Membrane Protein Band 4.9 (Dematin) (EPB49))
- 别名
- DMTN (EPB49 产品)
- 别名
- MGC80597 antibody, MGC108072 antibody, EPB49 antibody, DMT antibody, AI325486 antibody, Epb4.9 antibody, Epb49 antibody, dematin antibody, dematin actin binding protein L homeolog antibody, dematin actin binding protein antibody, dmtn.L antibody, DMTN antibody, dmtn antibody, Dmtn antibody
- 背景
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Description: Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Plays also a role as a modulator of actin dynamics in fibroblasts, acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation.
Gene: DMTN
- 分子量
- 45 kDa
- 基因ID
- 2039
- UniProt
- Q08495
- 途径
- Regulation of Actin Filament Polymerization
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