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IRS1 抗体 (pSer307)

Name: IRS1 抗体 (pSer307)
SKU: ABIN6255185
Availability: OutOfStock

IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of IRS-1 phosphorylation expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. (IRS1 抗体 (pSer307))

ABIN6267483 at 1/200 staining human liver cancer tissue sections by IHC-P. (IRS1 抗体 (pSer307))

IHC

IF/ICC

ABIN6267483 staining MCF-7 cells by ICC/IF. (IRS1 抗体 (pSer307))

IF/ICC

4 images

(3 references)

产品编号 ABIN6255185

发货至: 中国

Datasheet as PDF

抗原 See all IRS1 抗体

IRS1 (Insulin Receptor Substrate 1 (IRS1))
抗原表位
31

29

28

25

24

21

18

17

16

16

16

7

5

5

4

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
pSer307
适用
314

252

228

24

18

18

17

16

16

15

2

1

1
人, 小鼠, 大鼠, 猴
宿主
314

12
兔
Compatible Secondaries
克隆类型
308

18
多克隆
标记
136

14

11

10

10

10

10

10

10

10

10

10

10

10

10

9

6

6

6

6

6

6
This IRS1 antibody is un-conjugated
应用范围
169

126

104

92

91

65

61

48

24

18

11

7

4

2

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Phospho-IRS-1 (Ser307) Antibody detects endogenous levels of IRS-1 only when phosphorylated at Serine 307

交叉反应

人, 猴, 小鼠, 大鼠

纯化方法

The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.

免疫原

A synthesized peptide derived from human IRS-1 around the phosphorylation site of Serine 307

亚型

IgG

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Discover our top product IRS1 Primary Antibody
anti-Insulin Receptor Substrate 1 (IRS1) antibody
IRS1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer639) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer312) antibody
IRS1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (AA 1041-1242) antibody
IRS1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (AA 106-122), (N-Term) antibody
IRS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer636) antibody
IRS1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (Ser312) antibody
IRS1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (AA 274-323), (pSer307) antibody
IRS1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Insulin Receptor Substrate 1 (IRS1) (pSer1101) antibody
IRS1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000 IHC 1:50-1:200 IF/ICC 1:100-1:500

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C.Stable for 12 months from date of receipt

有效期

12 months
Geng, Zhu, Wang, Xie, Li, Wu, Li, Chen, Wang, Meng, Zhang, Chen, Zhong: "P53 modulates hepatic insulin sensitivity through NF-κB and p38/ERK MAPK pathways." in: Biochemical and biophysical research communications, Vol. 495, Issue 3, pp. 2139-2144, (2018) (PubMed).

Geng, Wang, Zhu, Xie, Li, Wu, Zhu, Jiang, Yang, Li, Chen, Wang, Meng, Zhong: "Curcumin suppresses JNK pathway to attenuate BPA-induced insulin resistance in LO2 cells." in: Biomedicine & pharmacotherapy, Vol. 97, pp. 1538-1543, (2018) (PubMed).

Geng, Wang, Zhu, Xie, Li, Wu, Zhu, Jiang, Yang, Li, Chen, Wang, Meng, Zhu, Wu, Huang, Zhong: "Curcumin attenuates BPA-induced insulin resistance in HepG2 cells through suppression of JNK/p38 pathways." in: Toxicology letters, Vol. 272, pp. 75-83, (2017) (PubMed).
抗原

IRS1 (Insulin Receptor Substrate 1 (IRS1))

别名

IRS-1 (IRS1 产品)

别名

HIRS-1 antibody, G972R antibody, IRS-1 antibody, IRS1IRM antibody, irs1 antibody, irsu antibody, IRS1 antibody, irs-1 antibody, irs1-a antibody, insulin receptor substrate 1 antibody, insulin receptor substrate 2 antibody, insulin receptor substrate 1 S homeolog antibody, IRS1 antibody, Irs1 antibody, irs2 antibody, irs1.S antibody

背景

Description: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Gene: IRS1

分子量

180kDa

基因ID

3667

UniProt

P35568

途径

Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process