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HNRNPK 抗体 (pSer284)

HNRNPK 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6255166
发货至: 中国
  • 抗原 See all HNRNPK 抗体
    HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))
    抗原表位
    • 15
    • 13
    • 10
    • 7
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer284
    适用
    • 82
    • 59
    • 55
    • 10
    • 10
    • 10
    • 7
    • 7
    • 7
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    人, 小鼠
    宿主
    • 75
    • 8
    克隆类型
    • 68
    • 15
    多克隆
    标记
    • 48
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HNRNPK antibody is un-conjugated
    应用范围
    • 61
    • 23
    • 20
    • 14
    • 14
    • 13
    • 12
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-hnRNP K (Ser284) Antibody detects endogenous levels of hnRNP K only when phosphorylated at Ser284.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human hnRNP K around the phosphorylation site of Ser284.
    亚型
    IgG
    Top Product
    Discover our top product HNRNPK Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))
    别名
    HNRNPK (HNRNPK 产品)
    别名
    CSBP antibody, HNRPK antibody, TUNP antibody, Csbp antibody, Hnrpk antibody, hnrpk antibody, MGC75642 antibody, wu:fb37h02 antibody, wu:fi34c04 antibody, zgc:66162 antibody, KBBP antibody, NOVA antibody, heterogeneous nuclear ribonucleoprotein K antibody, heterogeneous nuclear ribonucleoprotein K S homeolog antibody, heterogeneous nuclear ribonucleoprotein k antibody, HNRNPK antibody, Hnrnpk antibody, hnrnpk.S antibody, hnrnpk antibody, LOC5565718 antibody, CpipJ_CPIJ000130 antibody, NGK_p0004 antibody
    背景

    Description: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

    Gene: HNRNPK

    分子量
    51 kDa
    基因ID
    3190
    UniProt
    P61978
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