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FOXO3 抗体 (pSer253)

FOXO3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6255131
发货至: 中国
  • 抗原 See all FOXO3 抗体
    FOXO3 (Forkhead Box O3 (FOXO3))
    抗原表位
    • 33
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    • 9
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    pSer253
    适用
    • 165
    • 114
    • 105
    • 10
    • 8
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
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    • 1
    人, 小鼠, 大鼠
    宿主
    • 161
    • 5
    • 1
    • 1
    克隆类型
    • 153
    • 15
    多克隆
    标记
    • 69
    • 14
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 6
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    • 4
    • 1
    • 1
    • 1
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    • 1
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    This FOXO3 antibody is un-conjugated
    应用范围
    • 97
    • 59
    • 51
    • 31
    • 23
    • 15
    • 15
    • 14
    • 14
    • 12
    • 5
    • 3
    • 2
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    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-FOXO3A (Ser253) Antibody detects endogenous levels of FOXO3A only when phosphorylated at Serine 253.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human FOXO3A around the phosphorylation site of Ser253.
    亚型
    IgG
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • Yang, Lv, Chen, Wang, Liu, Shi, Liu, Wang: "The effect of vitamin D on sarcopenia depends on the level of physical activity in older adults." in: Journal of cachexia, sarcopenia and muscle, Vol. 11, Issue 3, pp. 678-689, (2021) (PubMed).

  • 抗原
    FOXO3 (Forkhead Box O3 (FOXO3))
    别名
    FOXO3 (FOXO3 产品)
    别名
    AF6q21 antibody, FKHRL1 antibody, FKHRL1P2 antibody, FOXO2 antibody, FOXO3A antibody, zgc:92176 antibody, wu:fb50g02 antibody, wu:fi33f07 antibody, Fkhrl1 antibody, Foxo3a antibody, FoxO3A antibody, 1110048B16Rik antibody, 2010203A17Rik antibody, C76856 antibody, Fkhr2 antibody, FOXO-3 antibody, FOXO3 antibody, foxo3a antibody, xfoxo3 antibody, foxO3 antibody, foxO antibody, fkhr antibody, foxo5 antibody, wu:fj65a12 antibody, zFkhr antibody, forkhead box O3 antibody, forkhead box O3A antibody, forkhead box O3 L homeolog antibody, forkhead box O3b antibody, FOXO3 antibody, foxo3a antibody, Foxo3 antibody, foxo3.L antibody, foxo3 antibody, foxO3 antibody, foxo3b antibody
    背景

    Description: Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' (PubMed:21329882). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301).

    Gene: FOXO3

    分子量
    97kDa
    基因ID
    2309
    UniProt
    O43524
    途径
    Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis
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