RIPK2 抗体 (pSer176)
-
- 抗原 See all RIPK2 抗体
- RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
-
抗原表位
- pSer176
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This RIPK2 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Phospho-RIPK2 (Ser176) Antibody detects endogenous levels of RIPK2 only when phosphorylated at Sersine 176.
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human RIPK2 around the phosphorylation site of Ser176.
- 亚型
- IgG
- Top Product
- Discover our top product RIPK2 Primary Antibody
-
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 431-540) antibody
RIPK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6F7 unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 431-540) antibodyRIPK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 7F5 unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 458-488), (C-Term) antibodyRIPK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03318 unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 458-488) antibodyRIPK2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 1-294) antibodyRIPK2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 1-540) antibodyRIPK2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (N-Term) antibodyRIPK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) antibodyKO Validated RIPK2 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (AA 432-540) antibodyRIPK2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting Serine-threonine Kinase 2 (RIPK2) (pSer176) antibodyRIPK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
-
- 抗原
- RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
- 别名
- RIPK2 (RIPK2 产品)
- 别名
- RIPK2 antibody, 2210420D18Rik antibody, CARD3 antibody, CARDIAK antibody, CCK antibody, D4Bwg0615e antibody, RICK antibody, RIP2 antibody, GIG30 antibody, receptor interacting serine/threonine kinase 2 antibody, receptor (TNFRSF)-interacting serine-threonine kinase 2 antibody, receptor-interacting serine-threonine kinase 2 antibody, RIPK2 antibody, Ripk2 antibody
- 背景
-
Description: Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited, RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP, BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn, NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
Gene: RIPK2
- 分子量
- 70kDa
- 基因ID
- 8767
- UniProt
- O43353
- 途径
- TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
-
