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p53 抗体 (acLys319)

TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of extracts from HeLa cells, treated with TSA 400nM 24h, using Acetyl-p53 (Lys317) Antibody. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining rat uterine tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining human skin tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining rat ovarian tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining human gastric tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining mouse gastric tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining mouse testicular tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining mouse brain tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining human TB tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 at 1/200 staining rat gastric tissue sections by IHC-P. (p53 抗体 (acLys319))

ABIN6267066 staining NIH/3T3 cells by IF/ICC. (p53 抗体 (acLys319))

11 images

产品编号 ABIN6254862

发货至: 中国

Datasheet as PDF

抗原 See all p53 (TP53) 抗体

p53 (TP53) (Tumor Protein P53 (TP53))
抗原表位
43

40

37

30

29

29

26

26

24

22

20

20

19

19

18

18

16

15

13

9

8

8

8

7

7

6

6

6

6

6

6

6

5

5

4

4

4

4

4

4

4

4

4

4

3

3

3

3

3

3
acLys319
适用
823

251

207

104

47

33

31

18

10

9

7

6

6

3

3

3

2

2

2

2

2

1

1

1
人, 小鼠, 大鼠
宿主
622

218

6

2

1
兔
Compatible Secondaries
克隆类型
558

290

1
多克隆
标记
476

38

31

19

18

13

13

13

13

13

13

13

13

13

12

11

11

11

11

11

11

11

11

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
This p53 antibody is un-conjugated
应用范围
661

297

247

199

198

148

124

122

119

64

58

32

18

16

13

12

9

9

8

6

4

3

3

2

2

2

1

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Acetyl-p53 (Lys319) Antibody detects endogenous levels of Acetyl-p53 only when acetylated at Lys319.

预测反应

Bovine

纯化方法

affinity purification

免疫原

A synthesized peptide derived from human p53 around the acetylation site of Lys319.

亚型

IgG

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TP53 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 2C11 unconjugated

anti-Tumor Protein P53 (TP53) (pSer20) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (pSer15) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:500-1:1000, IHC 1:50-1:500, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

p53 (TP53) (Tumor Protein P53 (TP53))

别名

TP53 (TP53 产品)

背景

Description: Acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis. Regulates the circadian clock by repressing CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER2 (PubMed:24051492).
Gene: TP53

分子量

53kDa

基因ID

7157

UniProt

P04637

途径

p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect

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