This antibody is purified through a protein A column, followed by peptide affinity purification.
免疫原
This CHRNE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 409-443 amino acids from the Central region of human CHRNE.
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.