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FLT1 抗体 (AA 1-380)

Name: FLT1 抗体 (AA 1-380)
SKU: ABIN6243861
Availability: OutOfStock

FLT1 适用: 人 WB 宿主: 小鼠 Monoclonal 1453CT519-277-79 unconjugated

All lanes : Anti-FLT1 Antibody at 1:2000 dilution Lane 1: human Liver lysates Lane 2: human placenta lysates Lysates/proteins at 20 μg per lane. (FLT1 抗体 (AA 1-380))

Anti-FLT1 Antibody at 1:2000 dilution + human lung lysates Lysates/proteins at 20 μg per lane. (FLT1 抗体 (AA 1-380))

2 images

产品编号 ABIN6243861

发货至: 中国

Datasheet as PDF

抗原 See all FLT1 抗体

FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
抗原表位
16

12

12

11

7

7

7

5

4

4

4

4

4

4

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1-380
适用
142

62

62

12

2

2

2

2

2

1

1

1

1

1

1

1
人
宿主
135

32

3

2
小鼠
Compatible Secondaries
克隆类型
139

33
单克隆
标记
90

23

11

4

4

4

4

4

4

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This FLT1 antibody is un-conjugated
应用范围
106

48

47

34

23

22

16

14

14

13

8

5

4

2

2

1

1

1
Western Blotting (WB)

纯化方法

This antibody is purified through a protein G column, followed by dialysis against PBS.

免疫原

This FLT1 antibody is generated from a mouse immunized with a recombinant protein.

克隆位点

1453CT519-277-79

亚型

IgG1 kappa

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FLT1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

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anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (pTyr1048) antibody
FLT1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 18-308) antibody
FLT1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1048-1328) antibody
FLT1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:2000. WB: 1:2000

限制

仅限研究用
状态

Liquid

缓冲液

Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
抗原

FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

别名

FLT1 (FLT1 产品)

别名

FLT antibody, FLT-1 antibody, VEGFR-1 antibody, VEGFR1 antibody, FLT1 antibody, flt1b antibody, sFlt1 antibody, AI323757 antibody, Flt-1 antibody, fms related tyrosine kinase 1 antibody, FMS-related tyrosine kinase 1 antibody, vascular endothelial growth factor receptor 1 antibody, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody, FMS-like tyrosine kinase 1 antibody, vascular endothelial growth factor receptor-1 antibody, FLT1 antibody, Flt1 antibody, CpipJ_CPIJ012087 antibody, flt1 antibody, FLT-1 antibody

背景

Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Likewise, isoforms lacking a transmembrane domain, such as isoform 2, isoform 3 and isoform 4, may function as decoy receptors for VEGFA. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1, and may also phosphorylate CBL. Isoform 1 phosphorylates PLCG. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1. Isoform 7 has a truncated kinase domain, it increases phosphorylation of SRC at 'Tyr-418' by unknown means and promotes tumor cell invasion.

分子量

150769

UniProt

P17948

途径

RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals