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- 抗原 See all CHMP4A 抗体
- CHMP4A (Charged Multivesicular Body Protein 4A (CHMP4A))
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抗原表位
- AA 205-239, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CHMP4A antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This CHMP4A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 205-239 amino acids from the C-terminal region of human CHMP4A.
- 克隆位点
- RB51700
- 亚型
- Ig Fraction
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anti-Charged Multivesicular Body Protein 4A (CHMP4A) (AA 1-222) antibody
CHMP4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4A (CHMP4A) (C-Term) antibodyCHMP4A 适用: 人, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4A (CHMP4A) (C-Term) antibodyCHMP4A 适用: 人, Cow, 兔, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- CHMP4A (Charged Multivesicular Body Protein 4A (CHMP4A))
- 别名
- CHMP4A (CHMP4A 产品)
- 别名
- C14orf123 antibody, CHMP4 antibody, CHMP4B antibody, HSPC134 antibody, SHAX2 antibody, SNF7 antibody, SNF7-1 antibody, VPS32-1 antibody, VPS32A antibody, charged multivesicular body protein 4A antibody, CHMP4A antibody
- 背景
- Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
- 分子量
- 25098
- UniProt
- Q9BY43
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